John L Pezzullo
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Explore the profile of John L Pezzullo including associated specialties, affiliations and a list of published articles.
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5
Citations
19
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Recent Articles
1.
Ciulla D, Xu Z, Pezzullo J, Dranchak P, Wang C, Giner J, et al.
Methods Enzymol
. 2023 May;
685:1-41.
PMID: 37245899
Paracatalytic inducers are antagonists that shift the specificity of biological catalysts, resulting in non-native transformations. In this Chapter we describe methods to discover paracatalytic inducers of Hedgehog (Hh) protein autoprocessing....
2.
Ciulla D, Dranchak P, Pezzullo J, Mancusi R, Psaras A, Rai G, et al.
J Biol Chem
. 2022 Nov;
298(12):102705.
PMID: 36400200
The Sonic Hedgehog (SHh) precursor protein undergoes biosynthetic autoprocessing to cleave off and covalently attach cholesterol to the SHh signaling ligand, a vital morphogen and oncogenic effector protein. Autoprocessing is...
3.
Wagner A, Stagnitta R, Xu Z, Pezzullo J, Kandel N, Giner J, et al.
Biochemistry
. 2021 Dec;
61(11):1022-1028.
PMID: 34941260
Hedgehog (Hh) signaling ligands undergo carboxy terminal sterylation through specialized autoprocessing, called cholesterolysis. Sterylation is brought about intramolecularly in a single turnover by an adjacent enzymatic domain, called HhC, which...
4.
Smith C, Wagner A, Stagnitta R, Xu Z, Pezzullo J, Giner J, et al.
Biochemistry
. 2020 Feb;
59(6):736-741.
PMID: 32013401
Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs through the action of...
5.
Ciulla D, Wagner A, Liu X, Cooper C, Jorgensen M, Wang C, et al.
Chem Commun (Camb)
. 2019 Jan;
55(12):1829-1832.
PMID: 30672911
Cholesterolysis of Hedgehog family proteins couples endoproteolysis to protein C-terminal sterylation. The transformation is self-catalyzed by HhC, a partially characterized enzymatic domain found in precursor forms of Hedgehog. Here we...