James Inglese
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Explore the profile of James Inglese including associated specialties, affiliations and a list of published articles.
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141
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5001
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Recent Articles
1.
McBride C, McCauley M, Harris N, Amin S, Verhey-Henke L, Teklemichael A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975215
Despite modern preventative and curative efforts, malaria has remained a major global health crisis. In 2023 alone, malaria was responsible for an estimated 263 million cases and 597,000 deaths. To...
2.
van Neer R, Dranchak P, Aitha M, Liu L, Carlson E, Jacobsen I, et al.
ACS Infect Dis
. 2025 Feb;
11(3):703-714.
PMID: 39903128
The secreted Chorismate mutase enzyme of (*CM) is an underexplored potential target for the development of new antitubercular agents that are increasingly needed as antibiotic resistance rises in prevalence. As...
3.
Bazargan S, Dranchak P, Liu C, Inglese J, Janiszewski J, Schneider B, et al.
bioRxiv
. 2025 Jan;
PMID: 39803517
We report the first implementation of ion mobility mass spectrometry combined with an ultra-high throughput sample introduction technology for high throughput screening (HTS). The system integrates differential ion mobility (DMS)...
4.
Bazargan S, Dranchak P, Liu C, Inglese J, Janiszewski J, Schneider B, et al.
Anal Chem
. 2024 Dec;
96(52):20645-20655.
PMID: 39698870
We report the first implementation of ion mobility mass spectrometry combined with an ultrahigh throughput sample introduction technology for high-throughput screening (HTS). The system integrates differential mobility spectrometry (DMS) with...
5.
Cheng Z, Aitha M, Thomas C, Sturgill A, Fairweather M, Hu A, et al.
J Chem Inf Model
. 2024 May;
64(10):3977-3991.
PMID: 38727192
The worldwide spread of the metallo-β-lactamases (MBL), especially New Delhi metallo-β-lactamase-1 (NDM-1), is threatening the efficacy of β-lactams, which are the most potent and prescribed class of antibiotics in the...
6.
Eastman R, Rusinova R, Herold K, Huang X, Dranchak P, Voss T, et al.
bioRxiv
. 2023 Nov;
PMID: 37961094
Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its...
7.
Rana S, Dranchak P, Dahlin J, Lamy L, Li W, Oliphant E, et al.
Cell Chem Biol
. 2023 Oct;
31(2):221-233.e14.
PMID: 37875111
Methotrexate (MTX) is a tight-binding dihydrofolate reductase (DHFR) inhibitor, used as both an antineoplastic and immunosuppressant therapeutic. MTX, like folate undergoes folylpolyglutamate synthetase-mediated γ-glutamylation, which affects cellular retention and target...
8.
Schmitt D, Dranchak P, Parajuli P, Blivis D, Voss T, Kohnhorst C, et al.
PLoS One
. 2023 Aug;
18(8):e0289707.
PMID: 37540718
We have previously demonstrated that human liver-type phosphofructokinase 1 (PFK1) recruits other rate-determining enzymes in glucose metabolism to organize multienzyme metabolic assemblies, termed glucosomes, in human cells. However, it has...
9.
Ciulla D, Xu Z, Pezzullo J, Dranchak P, Wang C, Giner J, et al.
Methods Enzymol
. 2023 May;
685:1-41.
PMID: 37245899
Paracatalytic inducers are antagonists that shift the specificity of biological catalysts, resulting in non-native transformations. In this Chapter we describe methods to discover paracatalytic inducers of Hedgehog (Hh) protein autoprocessing....
10.
Queme B, Braisted J, Dranchak P, Inglese J
J Cheminform
. 2023 Apr;
15(1):39.
PMID: 37004072
High throughput screening (HTS) is widely used in drug discovery and chemical biology to identify and characterize agents having pharmacologic properties often by evaluation of large chemical libraries. Standard HTS...