Brian P Callahan
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Explore the profile of Brian P Callahan including associated specialties, affiliations and a list of published articles.
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Citations
356
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Recent Articles
1.
Xu Z, Zhang X, Pal C, Rozners E, Callahan B
Bioorg Chem
. 2024 Dec;
154:108039.
PMID: 39705932
A modified enzyme fragment complementation assay has been designed and validated as a turn-on biosensor for nucleic acid detection in dilute aqueous solution. The assay is target sequence-agonistic and uses...
2.
Xu Z, Zhang X, Pal C, Rozners E, Callahan B
bioRxiv
. 2024 Jan;
PMID: 38187717
A modified protein fragment complementation assay has been designed and validated as a gain-of-signal biosensor for nucleic acid:nucleic acid interactions. The assay uses fragments of NanoBiT, the split luciferase reporter...
3.
Ciulla D, Xu Z, Pezzullo J, Dranchak P, Wang C, Giner J, et al.
Methods Enzymol
. 2023 May;
685:1-41.
PMID: 37245899
Paracatalytic inducers are antagonists that shift the specificity of biological catalysts, resulting in non-native transformations. In this Chapter we describe methods to discover paracatalytic inducers of Hedgehog (Hh) protein autoprocessing....
4.
Callahan B, Xu Z
Bioorg Med Chem
. 2023 Mar;
82:117231.
PMID: 36893527
A native enzyme's usual assurance in recognizing their physiological substrate(s) at the ground state and on going to the transition state can be undermined by interactions with selected small molecule...
5.
Ciulla D, Dranchak P, Pezzullo J, Mancusi R, Psaras A, Rai G, et al.
J Biol Chem
. 2022 Nov;
298(12):102705.
PMID: 36400200
The Sonic Hedgehog (SHh) precursor protein undergoes biosynthetic autoprocessing to cleave off and covalently attach cholesterol to the SHh signaling ligand, a vital morphogen and oncogenic effector protein. Autoprocessing is...
6.
Lennon C, Callahan B, Cousineau B, Edgell D, Belfort M
Front Mol Biosci
. 2022 Sep;
9:992664.
PMID: 36106021
No abstract available.
7.
Wagner A, Stagnitta R, Xu Z, Pezzullo J, Kandel N, Giner J, et al.
Biochemistry
. 2021 Dec;
61(11):1022-1028.
PMID: 34941260
Hedgehog (Hh) signaling ligands undergo carboxy terminal sterylation through specialized autoprocessing, called cholesterolysis. Sterylation is brought about intramolecularly in a single turnover by an adjacent enzymatic domain, called HhC, which...
8.
Zhang X, Kotikam V, Rozners E, Callahan B
Chembiochem
. 2021 Dec;
23(4):e202100594.
PMID: 34890095
Enzymatic beacons, or E-beacons, are 1 : 1 bioconjugates of the nanoluciferase enzyme linked covalently at its C-terminus to hairpin forming ssDNA equipped with a dark quencher. We prepared E-beacons...
9.
Zhang X, Kotikam V, Rozners E, Callahan B
bioRxiv
. 2021 Sep;
PMID: 34494022
Enzymatic beacons, or E-beacons, are 1:1 bioconjugates of the nanoluciferase enzyme linked covalently at its C-terminus to hairpin forming DNA oligonucleotides equipped with a dark quencher. We prepared E-beacons biocatalytically...
10.
Callahan B, Ciulla D, Wagner A, Xu Z, Zhang X
Biochemistry
. 2020 Sep;
59(38):3517-3522.
PMID: 32931253
We define paracatalysis as the acceleration of a reaction that appears abnormal or nonphysiological. With the high specificity of enzymes, side reactivity of this kind is typically negligible. However, enzyme...