Andrew G Wagner
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Explore the profile of Andrew G Wagner including associated specialties, affiliations and a list of published articles.
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6
Citations
28
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Recent Articles
1.
Wagner A, Lang T, Ledingham E, Ghosh A, Brooks D, Eskandari R, et al.
J Med Chem
. 2025 Jan;
68(3):3653-3672.
PMID: 39818772
DNPH1 is responsible for eliminating the epigenetically modified nucleotide, 5-hydroxymethyl-2'-deoxyuridine 5'-monophosphate (hmdUMP), preventing formation of hmdUTP, a mutation-inducing nucleotide. Loss of DNPH1 activity sensitizes PARP inhibition-resistant BRCA-deficient cancers by causing...
2.
Wagner A, Eskandari R, Schramm V
Anal Biochem
. 2023 May;
672:115171.
PMID: 37142196
2'-Deoxynucleoside 5'-monophosphate N-glycosidase 1 (DNPH1) hydrolyzes the epigenetically modified nucleotide 5-hydroxymethyl 2'-deoxyuridine 5'-monophosphate (hmdUMP) derived from DNA metabolism. Published assays of DNPH1 activity are low throughput, use high concentrations of...
3.
Wagner A, Stagnitta R, Xu Z, Pezzullo J, Kandel N, Giner J, et al.
Biochemistry
. 2021 Dec;
61(11):1022-1028.
PMID: 34941260
Hedgehog (Hh) signaling ligands undergo carboxy terminal sterylation through specialized autoprocessing, called cholesterolysis. Sterylation is brought about intramolecularly in a single turnover by an adjacent enzymatic domain, called HhC, which...
4.
Callahan B, Ciulla D, Wagner A, Xu Z, Zhang X
Biochemistry
. 2020 Sep;
59(38):3517-3522.
PMID: 32931253
We define paracatalysis as the acceleration of a reaction that appears abnormal or nonphysiological. With the high specificity of enzymes, side reactivity of this kind is typically negligible. However, enzyme...
5.
Smith C, Wagner A, Stagnitta R, Xu Z, Pezzullo J, Giner J, et al.
Biochemistry
. 2020 Feb;
59(6):736-741.
PMID: 32013401
Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs through the action of...
6.
Zhao J, Ciulla D, Xie J, Wagner A, Castillo D, Zwarycz A, et al.
J Am Chem Soc
. 2019 Nov;
141(46):18380-18384.
PMID: 31682419
Hedgehog (Hh) autoprocessing converts Hh precursor protein to cholesterylated Hh ligand for downstream signaling. A conserved active-site aspartate residue, D46, plays a key catalytic role in Hh autoprocessing by serving...
7.
Ciulla D, Wagner A, Liu X, Cooper C, Jorgensen M, Wang C, et al.
Chem Commun (Camb)
. 2019 Jan;
55(12):1829-1832.
PMID: 30672911
Cholesterolysis of Hedgehog family proteins couples endoproteolysis to protein C-terminal sterylation. The transformation is self-catalyzed by HhC, a partially characterized enzymatic domain found in precursor forms of Hedgehog. Here we...