John Koren 3rd
Overview
Explore the profile of John Koren 3rd including associated specialties, affiliations and a list of published articles.
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40
Citations
1369
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Recent Articles
1.
Sakthivel R, Criado-Marrero M, Barroso D, Braga I, Bolen M, Rubinovich U, et al.
J Neurotrauma
. 2023 Apr;
40(19-20):2037-2049.
PMID: 37051703
Repetitive mild traumatic brain injuries (rmTBIs) are serious trauma events responsible for the development of numerous neurodegenerative disorders. A major challenge in developing diagnostics and treatments for the consequences of...
2.
Cloyd R, Koren 3rd J, Abisambra J, Smith B
Exp Neurol
. 2021 May;
343:113766.
PMID: 34029610
Tauopathies, including Alzheimer's disease, are characterized by progressive accumulation of hyperphosphorylated and pathologic tau protein in association with onset of cognitive and behavioral impairment. Tau pathology is also associated with...
3.
Koren S, Hamm M, Cloyd R, Fontaine S, Chishti E, Lanzillotta C, et al.
Int J Mol Sci
. 2021 Feb;
22(3).
PMID: 33530349
Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This...
4.
Mishra S, Liu W, Beebe K, Banerjee M, Kent C, Munthali V, et al.
J Med Chem
. 2021 Jan;
64(3):1545-1557.
PMID: 33428418
The 90 kD heat shock proteins (Hsp90) are molecular chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inhibition...
5.
Luo Y, Medina Bengtsson L, Wang X, Huang T, Liu G, Murphy S, et al.
Sci Rep
. 2020 Sep;
10(1):15021.
PMID: 32929120
Ubiquinol-cytochrome c reductase hinge protein (UQCRH) is the hinge protein for the multi-subunit complex III of the mitochondrial electron transport chain and is involved in the electron transfer reaction between...
6.
Koren 3rd J, Blagg B
Adv Exp Med Biol
. 2020 Apr;
1243:135-146.
PMID: 32297216
Molecular chaperones are responsible for maintaining intracellular protein quality control by facilitating the conformational maturation of new proteins as well as the refolding of denatured proteins. While there are several...
7.
Darling A, Breydo L, Rivas E, Gebru N, Zheng D, Baker J, et al.
Int J Biol Macromol
. 2019 Jan;
127:136-145.
PMID: 30639592
A microsatellite expansion mutation in C9orf72 is the most common genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The expansion mutation leads to C9orf72 loss of function,...
8.
Kishinevsky S, Wang T, Rodina A, Chung S, Xu C, Philip J, et al.
Nat Commun
. 2018 Oct;
9(1):4345.
PMID: 30341316
Environmental and genetic risk factors contribute to Parkinson's Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we identify early PD pathogenic events by developing methodology that...
9.
Sabbagh J, Cordova R, Zheng D, Criado-Marrero M, Lemus A, Li P, et al.
ACS Chem Biol
. 2018 Jun;
13(8):2288-2299.
PMID: 29893552
Genetic and epigenetic alterations in FK506-binding protein 5 ( FKBP5) have been associated with increased risk for psychiatric disorders, including post-traumatic stress disorder (PTSD). Some of these common variants can...
10.
Huard D, Crowley V, Du Y, Cordova R, Sun Z, Tomlin M, et al.
ACS Chem Biol
. 2018 Feb;
13(4):933-941.
PMID: 29402077
Gain-of-function mutations within the olfactomedin (OLF) domain of myocilin result in its toxic intracellular accumulation and hasten the onset of open-angle glaucoma. The absence of myocilin does not cause disease;...