Jason E Gestwicki
Overview
Explore the profile of Jason E Gestwicki including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
229
Citations
13244
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zhang J, Greenwood N, Hernandez J, Cuperus J, Huang B, Ryder B, et al.
Cell Chem Biol
. 2025 Feb;
PMID: 39922190
Protein quality control (PQC) is carried out in part by the chaperone Hsp70 in concert with adapters of the J-domain protein (JDP) family. The JDPs, also called Hsp40s, are thought...
2.
Chung D, Connelly E, Unnikrishnan A, Chuo S, Wucherer K, Nadel C, et al.
J Biol Chem
. 2025 Jan;
301(3):108220.
PMID: 39863102
Carboxyl-terminus of Hsp70-Interacting Protein (CHIP) is an E3 ubiquitin ligase that marks misfolded substrates for degradation. Hyper-activation of CHIP has been implicated in multiple diseases, including cystic fibrosis and cancer,...
3.
Pokhrel S, Devi S, Gestwicki J
Trends Biochem Sci
. 2024 Dec;
50(2):121-133.
PMID: 39706778
The molecular chaperones HSP70 and HSP90 play key roles in proteostasis by acting as adapters; they bind to a 'client' protein, often with the assistance of cochaperones, and then recruit...
4.
Javed A, Johnson O, Balana A, Volk R, Langen A, Ahn B, et al.
Protein Sci
. 2024 Sep;
33(10):e5173.
PMID: 39291732
Almost all types of cellular stress induce post-translational O-GlcNAc modifications of proteins, and this increase promotes cell survival. We previously demonstrated that O-GlcNAc on certain small heat shock proteins (sHSPs),...
5.
Carroll E, Yang H, Jones J, Oehler A, Charvat A, Montgomery K, et al.
bioRxiv
. 2024 Sep;
PMID: 39282355
Aggregation of microtubule-associated protein tau (MAPT/tau) into conformationally distinct fibrils underpins neurodegenerative tauopathies. Fluorescent probes (fluoroprobes), such as thioflavin T (ThT), have been essential tools for studying tau aggregation; however,...
6.
Nadel C, Pokhrel S, Wucherer K, Oehler A, Thwin A, Basu K, et al.
Nat Commun
. 2024 Sep;
15(1):7972.
PMID: 39266525
Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer's disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is...
7.
Xu P, Yang J, Chen B, Ning S, Zhang X, Wang L, et al.
Nat Commun
. 2024 Aug;
15(1):6626.
PMID: 39103353
N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One potential way to circumvent the challenge of undruggable N-Myc is to target the protein homeostasis (proteostasis) system...
8.
Theofilas P, Wang C, Butler D, Morales D, Petersen C, Ambrose A, et al.
Mol Cell Neurosci
. 2024 Jul;
130:103954.
PMID: 39032719
Background: Tau post-translational modifications (PTMs) result in the gradual build-up of abnormal tau and neuronal degeneration in tauopathies, encompassing variants of frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). Tau...
9.
Braxton J, Shao H, Tse E, Gestwicki J, Southworth D
Nat Struct Mol Biol
. 2024 Jul;
31(12):1848-1858.
PMID: 38951622
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded proteins in the mitochondrial matrix, assisted by its co-chaperone mtHsp10. Despite its...
10.
Chen B, Xu P, Yang J, Nip C, Wang L, Shen Y, et al.
Oncogene
. 2024 Jun;
43(30):2325-2337.
PMID: 38877132
Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors, such as enzalutamide. However, the specific regulators and targets involved in...