Gabriela Chiosis
Overview
Explore the profile of Gabriela Chiosis including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
6235
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Recent Articles
1.
Alldred M, Ibrahim K, Pidikiti H, Lee S, Heguy A, Chiosis G, et al.
Front Mol Neurosci
. 2025 Mar;
18:1546375.
PMID: 40078964
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal...
2.
Bay S, Rodina A, Haut F, Roychowdhury T, Argyrousi E, Staniszewski A, et al.
Res Sq
. 2025 Feb;
PMID: 39989971
Alzheimer's disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we provide a systems-level map...
3.
Mahajan S, Grkovski M, Staton K, Ravassa S, Domfe K, Strauss H, et al.
Clin Transl Imaging
. 2025 Feb;
12(6):619-627.
PMID: 39935517
Background: The small molecule radiotracer I-PU-H71 is an imaging biomarker of epichaperome formation. The tracer has been established to localize in tissues under chronic stress, specifically in cancer cells and...
4.
Komives E, Chiosis G
Curr Opin Struct Biol
. 2024 Dec;
90:102953.
PMID: 39642844
No abstract available.
5.
Alldred M, Ibrahim K, Pidikiti H, Chiosis G, Mufson E, Stutzmann G, et al.
Acta Neuropathol Commun
. 2024 Nov;
12(1):182.
PMID: 39605035
Selective vulnerability of neuronal populations occurs in both Down syndrome (DS) and Alzheimer's disease (AD), resulting in disproportional degeneration of pyramidal neurons (PNs) affecting memory and executive function. Elucidating the...
6.
Que N, Seidler P, Aw W, Chiosis G, Gewirth D
Proteins
. 2024 Oct;
93(3):654-672.
PMID: 39473058
Grp94 is the endoplasmic reticulum paralog of the hsp90 family of chaperones, which have been targeted for therapeutic intervention via their highly conserved ATP binding sites. The design of paralog-selective...
7.
Roychowdhury T, McNutt S, Pasala C, Nguyen H, Thornton D, Sharma S, et al.
Nat Commun
. 2024 Oct;
15(1):8912.
PMID: 39414766
The intricate network of protein-chaperone interactions is crucial for maintaining cellular function. Recent discoveries have unveiled the existence of specialized chaperone assemblies, known as epichaperomes, which serve as scaffolding platforms...
8.
Guarra F, Sciva C, Bonollo G, Pasala C, Chiosis G, Moroni E, et al.
Cell Stress Chaperones
. 2024 Aug;
29(5):626-640.
PMID: 39142378
The heat shock protein 90 kDa (Hsp90) chaperone machinery plays a crucial role in maintaining cellular homeostasis. Beyond its traditional role in protein folding, Hsp90 is integral to key pathways...
9.
Magni A, Sciva C, Castelli M, Digwal C, Rodina A, Sharma S, et al.
Chemistry
. 2024 Jul;
30(54):e202401957.
PMID: 39042517
Post-translational modifications such as protein N-glycosylation, significantly influence cellular processes. Dysregulated N-glycosylation, exemplified in Grp94, a member of the Hsp90 family, leads to structural changes and the formation of epichaperomes,...
10.
Chakrabarty S, Wang S, Roychowdhury T, Ginsberg S, Chiosis G
Curr Opin Struct Biol
. 2024 Jul;
88:102886.
PMID: 39003916
Protein-protein interactions (PPIs) play a crucial role in cellular function and disease manifestation, with dysfunctions in PPI networks providing a direct link between stressors and phenotype. The dysfunctional Protein-Protein Interactome...