John K Sheehan
Overview
Explore the profile of John K Sheehan including associated specialties, affiliations and a list of published articles.
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30
Citations
1852
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Recent Articles
1.
Henderson A, Ehre C, Button B, Abdullah L, Cai L, Leigh M, et al.
J Clin Invest
. 2014 Jun;
124(7):3047-60.
PMID: 24892808
The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative...
2.
Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, et al.
Sci Rep
. 2012 Sep;
2:640.
PMID: 22962634
SIRT1, a NAD(+)-dependent protein deacetylase, is an important regulator in cellular stress response and energy metabolism. While the list of SIRT1 substrates is growing, how the activity of SIRT1 is...
3.
Button B, Cai L, Ehre C, Kesimer M, Hill D, Sheehan J, et al.
Science
. 2012 Aug;
337(6097):937-41.
PMID: 22923574
Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel is propelled on top...
4.
Cao R, Wang T, DeMaria G, Sheehan J, Kesimer M
J Proteome Res
. 2012 Jun;
11(8):4013-23.
PMID: 22663354
Mucin genes encode a family of the largest expressed proteins in the human genome. The proteins are highly substituted with O-linked oligosaccharides that greatly restrict access to the peptide backbones....
5.
Abdullah L, Wolber C, Kesimer M, Sheehan J, Davis C
Methods Mol Biol
. 2012 Jan;
842:259-77.
PMID: 22259142
Mucin secretion is regulated by extracellular signaling molecules emanating from local, neuronal, or endocrine sources. Quantifying the rate of this secretion is important to understanding how the exocytic process is...
6.
Kesimer M, Sheehan J
Methods Mol Biol
. 2012 Jan;
842:67-79.
PMID: 22259130
Mucins are difficult to handle for their identification and characterization via proteomic applications due to their heavily glycosylated nature (up to 90%), high molecular weight (200 kDa-200 MDa), and size...
7.
Sears P, Davis C, Chua M, Sheehan J
Am J Physiol Lung Cell Mol Physiol
. 2011 May;
301(2):L181-6.
PMID: 21531774
The airway epithelial surface liquid is generally considered to be composed of two layers, a periciliary layer and a continuous thick mucus layer moving in bulk. This view may not...
8.
Kesimer M, Makhov A, Griffith J, Verdugo P, Sheehan J
Am J Physiol Lung Cell Mol Physiol
. 2009 Sep;
298(1):L15-22.
PMID: 19783639
Gel-forming mucins are the largest complex glycoprotein macromolecules in the body. They form the matrix of gels protecting all the surface epithelia and are secreted as disulfide-bonded polymeric structures. The...
9.
Kesimer M, Kilic N, Mehrotra R, Thornton D, Sheehan J
BMC Microbiol
. 2009 Aug;
9:163.
PMID: 19671172
Background: The salivary mucin MUC7 (previously known as MG2) can adhere to various strains of streptococci that are primary colonizers and predominant microorganisms of the oral cavity. Although there is...
10.
Blundell C, Roberts I, Sheehan J, Almond A
J Mol Microbiol Biotechnol
. 2009 Apr;
17(2):71-82.
PMID: 19401610
The capsular polysaccharide of Escherichia coli K5 has been hypothesised to promote virulence through its molecular mimicry of host heparan sulphate. To test this hypothesis, we have produced pure oligosaccharides...