David J Thornton
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Explore the profile of David J Thornton including associated specialties, affiliations and a list of published articles.
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91
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3928
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Recent Articles
1.
Mair I, Bennett A, Forman R, Othman A, Logunova L, Smith H, et al.
Parasite Immunol
. 2024 Oct;
46(11):e13072.
PMID: 39480064
For decades, parasitic worms such as Trichuris muris have been maintained in laboratory animals, providing insights into host-parasite interactions and host immune responses. The most used T. muris isolate is...
2.
Dubaissi E, Hilton E, Lilley S, Collins R, Holt C, March P, et al.
Sci Rep
. 2024 Oct;
14(1):25555.
PMID: 39461969
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A...
3.
Kishimoto H, Ridley C, Inoue K, Thornton D
PLoS One
. 2024 Jun;
19(6):e0306058.
PMID: 38935605
Mucosal-delivered drugs have to pass through the mucus layer before absorption through the epithelial cell membrane. Although there has been increasing interest in polymeric mucins, a major structural component of...
4.
Bennett A, Mair I, Muir A, Smith H, Logunova L, Wolfenden A, et al.
Sci Rep
. 2024 Mar;
14(1):6954.
PMID: 38521809
Mucin protein glycosylation is important in determining biological properties of mucus gels, which form protective barriers at mucosal surfaces of the body such as the intestine. Ecological factors including: age,...
5.
Herrera J, Dingle L, Monetero M, Venkateswaran R, Blaikley J, Granato F, et al.
Respir Res
. 2023 Apr;
24(1):99.
PMID: 37005656
Honeycombing is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). Honeycombing refers to cystic airways located at sites of dense fibrosis with marked mucus accumulation. Utilizing laser capture microdissection...
6.
Fass D, Thornton D
Curr Opin Struct Biol
. 2023 Feb;
79:102524.
PMID: 36753925
Contrary to first appearances, mucus structural biology is not an oxymoron. Though mucus hydrogels derive their characteristics largely from intrinsically disordered, heavily glycosylated polypeptide segments, the secreted mucin glycoproteins that...
7.
Funjika E, Colombo S, Hayes K, Tozer M, Tyrrell K, Cai S, et al.
Mucosal Immunol
. 2023 Jan;
16(1):27-38.
PMID: 36690078
Gastrointestinal nematode infections cause morbidity and socioeconomic loss in the most deprived communities. The shift in the context of obesity has led to spatial overlap with endemic gastrointestinal nematode regions...
8.
Ehre C, Hansson G, Thornton D, Ostedgaard L
J Cyst Fibros
. 2022 Sep;
22 Suppl 1:S23-S26.
PMID: 36117114
Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus accumulation in the lungs, the intestinal...
9.
Kishimoto H, Ridley C, Thornton D
Sci Rep
. 2022 Apr;
12(1):6153.
PMID: 35418571
Cyclic peptides are good candidates for orally delivered therapeutics, however, issues remain in their development due to low intestinal permeability. Although some of the biological factors have been reported that...
10.
Duque-Correa M, Goulding D, Rodgers F, Gillis J, Cormie C, Rawlinson K, et al.
Nat Commun
. 2022 Apr;
13(1):1725.
PMID: 35365634
Whipworms are large metazoan parasites that inhabit multi-intracellular epithelial tunnels in the large intestine of their hosts, causing chronic disease in humans and other mammals. How first-stage larvae invade host...