Johannes D Clausen
Overview
Explore the profile of Johannes D Clausen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
393
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Geurts M, Clausen J, Arnou B, Montigny C, Lenoir G, Corey R, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(49):31114-31122.
PMID: 33229570
The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) is a P-type ATPase that transports Ca from the cytosol into the sarco(endo)plasmic reticulum (SR/ER) lumen, driven by ATP. This primary transport activity depends on...
2.
Cohrt K, Marin L, Kjellerup L, Clausen J, Dalby-Brown W, Antonio Calera J, et al.
Antimicrob Agents Chemother
. 2018 Feb;
62(5).
PMID: 29439980
An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel...
3.
Bublitz M, Kjellerup L, Cohrt K, Gordon S, Mortensen A, Clausen J, et al.
PLoS One
. 2018 Jan;
13(1):e0188620.
PMID: 29293507
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data...
4.
Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives
Clausen J, Kjellerup L, Cohrt K, Hansen J, Dalby-Brown W, Winther A
Bioorg Med Chem Lett
. 2017 Sep;
27(19):4564-4570.
PMID: 28893470
Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H-ATPase) inhibitors with a broad spectrum of antifungal activity. The carbazole compounds inhibit...
5.
Clausen J, Bublitz M, Arnou B, Olesen C, Andersen J, Moller J, et al.
Structure
. 2016 Apr;
24(4):617-623.
PMID: 27050689
Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have determined the crystal structure of sarcoplasmic reticulum Ca(2+)-ATPase...
6.
Clausen J, McIntosh D, Woolley D, Andersen J
Methods Mol Biol
. 2015 Dec;
1377:233-59.
PMID: 26695037
The photoactivation of aryl azides is commonly employed as a means to covalently attach cross-linking and labeling reagents to proteins, facilitated by the high reactivity of the resultant aryl nitrenes...
7.
Bublitz M, Nass K, Drachmann N, Markvardsen A, Gutmann M, Barends T, et al.
IUCrJ
. 2015 Jul;
2(Pt 4):409-20.
PMID: 26175901
Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently, membrane proteins are targeted by a large number of...
8.
Clausen J, Holdensen A, Andersen J
J Biol Chem
. 2014 Sep;
289(42):29123-34.
PMID: 25193668
ATP has dual roles in the reaction cycle of sarcoplasmic reticulum Ca(2+)-ATPase. Upon binding to the Ca2E1 state, ATP phosphorylates the enzyme, and by binding to other conformational states in...
9.
Clausen J, Bublitz M, Arnou B, Montigny C, Jaxel C, Moller J, et al.
EMBO J
. 2013 Nov;
32(24):3231-43.
PMID: 24270570
The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) couples ATP hydrolysis to transport of Ca(2+). This directed energy transfer requires cross-talk between the two Ca(2+) sites and the phosphorylation site over 50 Å...
10.
Clausen J, Vandecaetsbeek I, Wuytack F, Vangheluwe P, Andersen J
J Biol Chem
. 2012 Oct;
287(47):39460-9.
PMID: 23024360
The molecular mechanism underlying the characteristic high apparent Ca(2+) affinity of SERCA2b relative to SERCA1a and SERCA2a isoforms was studied. The C-terminal tail of SERCA2b consists of an 11th transmembrane...