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Robert Lea

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Articles 30
Citations 707
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Recent Articles
1.
Hawley J, Lea R, Biga V, Papalopulu N, Manning C
Biol Open . 2025 Jan; 14(1). PMID: 39835478
In the developing mouse ventral spinal cord, HES5, a transcription factor downstream of Notch signalling, is expressed as evenly spaced clusters of high HES5-expressing neural progenitor cells along the dorsoventral...
2.
Doostdar P, Hawley J, Chopra K, Marinopoulou E, Lea R, Arashvand K, et al.
Development . 2024 Apr; 151(10). PMID: 38682303
This paper investigates the effect of altering the protein expression dynamics of the bHLH transcription factor Her6 at the single-cell level in the embryonic zebrafish telencephalon. Using a homozygote endogenous...
3.
Tzung K, Lalonde R, Prummel K, Mahabaleshwar H, Moran H, Stundl J, et al.
Nature . 2023 May; 618(7965):543-549. PMID: 37225983
The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis...
4.
Soto X, Burton J, Manning C, Minchington T, Lea R, Lee J, et al.
Development . 2022 Oct; 149(19). PMID: 36189829
MicroRNAs (miRs) have an important role in tuning dynamic gene expression. However, the mechanism by which they are quantitatively controlled is unknown. We show that the amount of mature miR-9,...
5.
Bottiglione F, Dee C, Lea R, Zeef L, Badrock A, Wane M, et al.
J Immunol . 2020 Jul; 205(4):994-1008. PMID: 32641385
Mucosal surfaces such as fish gills interface between the organism and the external environment and as such are major sites of foreign Ag encounter. In the gills, the balance between...
6.
Soto X, Biga V, Kursawe J, Lea R, Doostdar P, Thomas R, et al.
EMBO J . 2020 May; 39(12):e103558. PMID: 32395844
Noise is prevalent in biology and has been widely quantified using snapshot measurements. This static view obscures our understanding of dynamic noise properties and how these affect gene expression and...
7.
Zhang S, Li J, Lea R, Amaya E
J Vis Exp . 2016 May; (110):e53949. PMID: 27166855
Primary neurogenesis is a dynamic and complex process during embryonic development that sets up the initial layout of the central nervous system. During this process, a portion of neural stem...
8.
Harris F, Prabhu S, Dennison S, Snape T, Lea R, Mura M, et al.
Protein Pept Lett . 2016 May; 23(8):676-87. PMID: 27165406
It is becoming increasingly clear that plants ranging across the plant kingdom produce anionic host defence peptides (AHDPs) with potent activity against a wide variety of human cancers cells. In...
9.
Sabherwal N, Thuret R, Lea R, Stanley P, Papalopulu N
Dev Cell . 2014 Dec; 31(5):559-71. PMID: 25490266
During the development of the nervous system, apicobasally polarized stem cells are characterized by a shorter cell cycle than nonpolar progenitors, leading to a lower differentiation potential of these cells....
10.
Zhang S, Li J, Lea R, Vleminckx K, Amaya E
Development . 2014 Dec; 141(24):4794-805. PMID: 25468942
Brain regionalisation, neuronal subtype diversification and circuit connectivity are crucial events in the establishment of higher cognitive functions. Here we report the requirement for the transcriptional repressor Fezf2 for proper...