Joanna Groden
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Explore the profile of Joanna Groden including associated specialties, affiliations and a list of published articles.
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54
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2076
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Recent Articles
1.
Kaul Z, Cheung C, Bhargava P, Sari A, Yu Y, Huifu H, et al.
Sci Rep
. 2021 Aug;
11(1):17052.
PMID: 34426596
Activation of a telomere length maintenance mechanism (TMM), including telomerase and alternative lengthening of telomeres (ALT), is essential for replicative immortality of tumor cells, although its regulatory mechanisms are incompletely...
2.
Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):33466-33473.
PMID: 33318203
Rare biallelic gene mutations cause Bloom syndrome. Whether heterozygous germline mutations () cause human cancer remains unclear. We sequenced the germline DNA of 155 mesothelioma patients (33 familial and 122...
3.
Hankey W, Chen Z, Bergman M, Fernandez M, Hancioglu B, Lan X, et al.
Oncotarget
. 2018 Aug;
9(58):31214-31230.
PMID: 30131849
Mutation of the gene occurs in a high percentage of colorectal tumors and is a central event driving tumor initiation in the large intestine. The APC protein performs multiple tumor...
4.
Behnfeldt J, Acharya S, Tangeman L, Gocha A, Keirsey J, Groden J
Hum Mol Genet
. 2018 Feb;
27(7):1241-1251.
PMID: 29385443
The recQ-like helicase BLM interacts directly with topoisomerase IIα to regulate chromosome breakage in human cells. We demonstrate that a phosphosite tri-serine cluster (S577/S579/S580) within the BLM topoisomerase IIα-interaction region...
5.
Hankey W, Frankel W, Groden J
Cancer Metastasis Rev
. 2018 Jan;
37(1):159-172.
PMID: 29318445
The acquisition of biallelic mutations in the APC gene is a rate-limiting step in the development of most colorectal cancers and occurs in the earliest lesions. APC encodes a 312-kDa...
6.
Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients
Hankey W, McIlhatton M, Ebede K, Kennedy B, Hancioglu B, Zhang J, et al.
Cancer Res
. 2017 Dec;
78(3):617-630.
PMID: 29212857
biallelic loss-of-function mutations are the most prevalent genetic changes in colorectal tumors, but it is unknown whether these mutations phenocopy gain-of-function mutations in the gene encoding β-catenin that also activate...
7.
Martinez A, Kaul Z, Parvin J, Groden J
Genes Chromosomes Cancer
. 2017 Apr;
56(8):617-631.
PMID: 28398700
Cancer cells require telomere maintenance to enable uncontrolled growth. Most often telomerase is activated, although a subset of human cancers are telomerase-negative and depend on recombination-based mechanisms known as ALT...
8.
Trimarchi M, Yan P, Groden J, Bundschuh R, Goodfellow P
PLoS One
. 2017 Mar;
12(3):e0173242.
PMID: 28278225
Background: DNA methylation is a stable epigenetic mark that is frequently altered in tumors. DNA methylation features are attractive biomarkers for disease states given the stability of DNA methylation in...
9.
Tangeman L, McIlhatton M, Grierson P, Groden J, Acharya S
Genes (Basel)
. 2016 Sep;
7(9).
PMID: 27657136
Defects in coordinated ribosomal RNA (rRNA) transcription in the nucleolus cause cellular and organismal growth deficiencies. Bloom's syndrome, an autosomal recessive human disorder caused by mutated recQ-like helicase BLM, presents...
10.
Yu Y, Gao R, Kaul Z, Li L, Kato Y, Zhang Z, et al.
Sci Rep
. 2016 Jul;
6:30185.
PMID: 27457128
Significance of microRNAs (miRs), small non-coding molecules, has been implicated in a variety of biological processes. Here, we recruited retroviral insertional mutagenesis to obtain induction of an arbitrary noncoding RNAs,...