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Saumitri Bhattacharyya

Explore the profile of Saumitri Bhattacharyya including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 209
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Recent Articles
1.
Grierson P, Lillard K, Behbehani G, Combs K, Bhattacharyya S, Acharya S, et al.
Hum Mol Genet . 2011 Nov; 21(5):1172-83. PMID: 22106380
Bloom's syndrome (BS) is an autosomal recessive disorder that is invariably characterized by severe growth retardation and cancer predisposition. The Bloom's syndrome helicase (BLM), mutations of which lead to BS,...
2.
Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, Perchiniak E, et al.
Cancer Res . 2011 Jan; 71(2):561-71. PMID: 21224348
Cells deficient in the recQ-like helicase BLM are characterized by chromosome changes that suggest the disruption of normal mechanisms needed to resolve recombination intermediates and to maintain chromosome stability. Human...
3.
Bhattacharyya S, Sandy A, Groden J
J Cell Biochem . 2009 Nov; 109(1):7-15. PMID: 19911388
Telomeres are composed of specialized chromatin that includes DNA repair/recombination proteins, telomere DNA-binding proteins and a number of three dimensional nucleic acid structures including G-quartets and D-loops. A number of...
4.
Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard-Wetherell K, Tahmaseb K, et al.
J Biol Chem . 2009 Mar; 284(22):14966-77. PMID: 19329795
The BLM helicase associates with the telomere structural proteins TRF1 and TRF2 in immortalized cells using the alternative lengthening of telomere (ALT) pathways. This work focuses on identifying protein partners...
5.
Collins N, Bhattacharyya S, Lahue R
DNA Repair (Amst) . 2006 Sep; 6(1):38-44. PMID: 16979389
Trinucleotide repeats (TNRs) frequently expand in certain human genetic diseases, often with devastating pathological consequences. TNR expansions require the addition of new DNA; accordingly, molecular models suggest aberrant DNA replication...
6.
Bhattacharyya S, Lahue R
J Biol Chem . 2005 Aug; 280(39):33311-7. PMID: 16085654
Trinucleotide repeat expansions are the mutational cause of at least 15 genetic diseases. In vitro, single-stranded triplet repeat DNA forms highly stable hairpins, depending on repeat sequence, and a strong...
7.
Bhattacharyya S, Lahue R
Mol Cell Biol . 2004 Aug; 24(17):7324-30. PMID: 15314145
Trinucleotide repeats (TNRs) undergo frequent mutations in families afflicted with certain neurodegenerative disorders and in model organisms. TNR instability is modulated both by the repeat tract itself and by cellular...
8.
Dixon M, Bhattacharyya S, Lahue R
Methods Mol Biol . 2004 Jun; 277:29-45. PMID: 15201447
The unusual genetic features of trinucleotide repeat (TNR) diseases have stimulated a substantial body of research into the underlying molecular mechanisms of repeat instability. As one useful tool to study...
9.
Bhattacharyya S, Rolfsmeier M, Dixon M, Wagoner K, Lahue R
Genetics . 2002 Oct; 162(2):579-89. PMID: 12399373
Trinucleotide repeats (TNRs) undergo frequent mutations in families affected by TNR diseases and in model organisms. Much of the instability is conferred in cis by the sequence and length of...