Joan W Conaway
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Explore the profile of Joan W Conaway including associated specialties, affiliations and a list of published articles.
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76
Citations
4431
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Recent Articles
1.
Herlihy A, Boeing S, Weems J, Walker J, Dirac-Svejstrup A, Lehner M, et al.
DNA Repair (Amst)
. 2022 May;
115:103343.
PMID: 35633597
During transcription, RNA polymerase II (RNAPII) faces numerous obstacles, including DNA damage, which can lead to stalling or arrest. One mechanism to contend with this situation is ubiquitylation and degradation...
2.
Suzuki H, Abe R, Shimada M, Hirose T, Hirose H, Noguchi K, et al.
Nat Commun
. 2022 May;
13(1):2905.
PMID: 35614107
Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with Cajal bodies (CBs), in which 3'-end processing...
3.
Krishnan J, Seidel C, Zhang N, Singh N, VanCampen J, Peuss R, et al.
Nat Genet
. 2022 May;
54(5):684-693.
PMID: 35551306
Cis-regulatory changes are key drivers of adaptative evolution. However, their contribution to the metabolic adaptation of organisms is not well understood. Here, we used a unique vertebrate model, Astyanax mexicanus-different...
4.
Conkright-Fincham J, Tomomori-Sato C, McGhee R, Leslie E, Beucher C, Weems L, et al.
Bio Protoc
. 2022 Feb;
12(2):e4301.
PMID: 35127991
The SARS-CoV-2 pandemic and vaccination campaign has illustrated the need for high throughput serological assays to quantitatively measure antibody levels. Here, we present a protocol for a high-throughput colorimetric ELISA...
5.
He Y, Sato S, Tomomori-Sato C, Chen S, Goode Z, Conaway J, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34544872
The bZIP transcription factor ATF6α is a master regulator of endoplasmic reticulum (ER) stress response genes. In this report, we identify the multifunctional RNA polymerase II transcription factor Elongin as...
6.
Ooi S, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(36).
PMID: 34465625
The SNF2 family ATPase Amplified in Liver Cancer 1 (ALC1) is the only chromatin remodeling enzyme with a poly(ADP-ribose) (PAR) binding macrodomain. ALC1 functions together with poly(ADP-ribose) polymerase PARP1 to...
7.
Weems J, Slaughter B, Unruh J, Weaver K, Miller B, Delventhal K, et al.
J Biol Chem
. 2021 Jun;
297(1):100862.
PMID: 34116057
The Elongin complex was originally identified as an RNA polymerase II (RNAPII) elongation factor and subsequently as the substrate recognition component of a Cullin-RING E3 ubiquitin ligase. More recent evidence...
8.
Singh N, De Kumar B, Paulson A, Parrish M, Zhang Y, Florens L, et al.
Genes Dev
. 2020 Nov;
34(23-24):1680-1696.
PMID: 33184220
Gene duplication and divergence is a major driver in the emergence of evolutionary novelties. How variations in amino acid sequences lead to loss of ancestral activity and functional diversification of...
9.
Yasukawa T, Tsutsui A, Tomomori-Sato C, Sato S, Saraf A, Washburn M, et al.
Cell Rep
. 2020 Mar;
30(10):3478-3491.e6.
PMID: 32160551
Alzheimer's disease (AD) is a progressive neurodegenerative disease caused by accumulations of Aβ peptides. Production and fibrillation of Aβ are downregulated by BRI2 and BRI3, which are physiological inhibitors of...
10.
Tufegdzic Vidakovic A, Mitter R, Kelly G, Neumann M, Harreman M, Rodriguez-Martinez M, et al.
Cell
. 2020 Mar;
180(6):1245-1261.e21.
PMID: 32142654
In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into...