Ronald C Conaway
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Explore the profile of Ronald C Conaway including associated specialties, affiliations and a list of published articles.
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102
Citations
6709
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Recent Articles
1.
Herlihy A, Boeing S, Weems J, Walker J, Dirac-Svejstrup A, Lehner M, et al.
DNA Repair (Amst)
. 2022 May;
115:103343.
PMID: 35633597
During transcription, RNA polymerase II (RNAPII) faces numerous obstacles, including DNA damage, which can lead to stalling or arrest. One mechanism to contend with this situation is ubiquitylation and degradation...
2.
Suzuki H, Abe R, Shimada M, Hirose T, Hirose H, Noguchi K, et al.
Nat Commun
. 2022 May;
13(1):2905.
PMID: 35614107
Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with Cajal bodies (CBs), in which 3'-end processing...
3.
He Y, Sato S, Tomomori-Sato C, Chen S, Goode Z, Conaway J, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34544872
The bZIP transcription factor ATF6α is a master regulator of endoplasmic reticulum (ER) stress response genes. In this report, we identify the multifunctional RNA polymerase II transcription factor Elongin as...
4.
Ooi S, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(36).
PMID: 34465625
The SNF2 family ATPase Amplified in Liver Cancer 1 (ALC1) is the only chromatin remodeling enzyme with a poly(ADP-ribose) (PAR) binding macrodomain. ALC1 functions together with poly(ADP-ribose) polymerase PARP1 to...
5.
Weems J, Slaughter B, Unruh J, Weaver K, Miller B, Delventhal K, et al.
J Biol Chem
. 2021 Jun;
297(1):100862.
PMID: 34116057
The Elongin complex was originally identified as an RNA polymerase II (RNAPII) elongation factor and subsequently as the substrate recognition component of a Cullin-RING E3 ubiquitin ligase. More recent evidence...
6.
Yasukawa T, Tsutsui A, Tomomori-Sato C, Sato S, Saraf A, Washburn M, et al.
Cell Rep
. 2020 Mar;
30(10):3478-3491.e6.
PMID: 32160551
Alzheimer's disease (AD) is a progressive neurodegenerative disease caused by accumulations of Aβ peptides. Production and fibrillation of Aβ are downregulated by BRI2 and BRI3, which are physiological inhibitors of...
7.
Tufegdzic Vidakovic A, Mitter R, Kelly G, Neumann M, Harreman M, Rodriguez-Martinez M, et al.
Cell
. 2020 Mar;
180(6):1245-1261.e21.
PMID: 32142654
In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into...
8.
Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, et al.
Nat Commun
. 2020 Feb;
11(1):1063.
PMID: 32102997
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex...
9.
Conaway R, Conaway J
Nat Struct Mol Biol
. 2019 Aug;
26(9):771-776.
PMID: 31439940
The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic transcription factors. Here we describe this...
10.
Tettey T, Gao X, Shao W, Li H, Story B, Chitsazan A, et al.
Cell Rep
. 2019 Jun;
27(13):3770-3779.e7.
PMID: 31242411
FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro....