Jin-Qiang Hou
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Explore the profile of Jin-Qiang Hou including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
298
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Recent Articles
1.
Guo X, Shi D, Huang S, Zhang Y, Zhang W, Chen J, et al.
J Med Chem
. 2025 Jan;
68(3):2804-2814.
PMID: 39807685
Positron emission tomography (PET) is a common imaging technique and can provide accurate information about the size, shape, and location of tumors. Recent evidence has shown that G-quadruplex structures (G4s)...
2.
Li D, Hou J, Long W, Lu Y, Wong W, Zhang K
RSC Adv
. 2022 May;
8(41):22931.
PMID: 35543993
[This corrects the article DOI: 10.1039/C8RA03833C.].
3.
Li D, Hou J, Long W, Lu Y, Wong W, Zhang K
RSC Adv
. 2022 May;
8(36):20222-20227.
PMID: 35541662
A symmetric ligand is synthesized composed of a core -methylpyridinium scaffold and two -substituted benzyl groups through a flexible ethylene bridge to form a novel three-ring-conjugated system. The ligand system...
4.
Long W, Zheng B, Li Y, Huang X, Lin D, Chen C, et al.
Nucleic Acids Res
. 2022 Feb;
50(4):1829-1848.
PMID: 35166828
DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures...
5.
Zheng B, She M, Long W, Xu Y, Zhang Y, Huang X, et al.
Chem Commun (Camb)
. 2020 Nov;
56(95):15016-15019.
PMID: 33185205
A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell...
6.
Lu Y, Deng Q, Hou J, Hu D, Wang Z, Zhang K, et al.
ACS Chem Biol
. 2016 Jan;
11(4):1019-29.
PMID: 26752011
The universal fluorescent staining property of thiazole orange (TO) dye was adapted in order to be specific for G-quadruplex DNA structures, through the introduction of a styrene-like substituent at the...
7.
Shan C, Lin J, Hou J, Liu H, Chen S, Chen A, et al.
Nucleic Acids Res
. 2015 Jun;
43(14):6677-91.
PMID: 26117539
c-MYC is an important oncogene that is considered as an effective target for anticancer therapy. Regulation of this gene's transcription is one avenue for c-MYC-targeting drug design. Direct binding to...
8.
Hou J, Chen S, Zan L, Ou T, Tan J, Luyt L, et al.
Chem Commun (Camb)
. 2014 Nov;
51(1):198-201.
PMID: 25388435
To efficiently identify small molecules binding to a G-quadruplex structure while avoiding binding to duplex DNA, we performed a multistep structure-based virtual screening by simultaneously taking into account G-quadruplex DNA...
9.
Wang X, Zhou C, Yan J, Hou J, Chen S, Ou T, et al.
ACS Med Chem Lett
. 2014 Jun;
4(10):909-14.
PMID: 24900584
The c-KIT G-quadruplex structures are a novel class of attractive targets for the treatment of gastrointestinal stromal tumor (GIST). Herein, a series of new quinazolone derivatives with the expansion of...
10.
Li Y, Weng X, Ning F, Ou J, Hou J, Luo H, et al.
J Mol Graph Model
. 2013 Mar;
41:61-7.
PMID: 23500628
In the present study, a series of novel azaoxoisoaporphine derivatives were reported and their inhibitory activities toward acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Aβ aggregation were evaluated. The new compounds remained...