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Shuo-Bin Chen

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Articles 72
Citations 580
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Recent Articles
1.
Tang G, Zeng S, Wang J, Yan J, Chen S, Huang Z, et al.
Anal Chem . 2025 Feb; 97(8):4387-4396. PMID: 39968811
RNA granules are liquid-liquid-phase-separated condensates comprising RNA and proteins. Despite growing insights into their biological functions, studies have predominantly relied on biological methodologies lacking adequate chemical tools. Here, we introduce...
2.
Xu C, Shi Y, Zhang W, Yang J, Zhang X, Chen S, et al.
J Nat Prod . 2025 Feb; 88(2):477-484. PMID: 39895290
Cytochalasins are notable for their structural diversity and broad range of biological activities. The gene cluster responsible for the biosynthesis of cytochalasins bearing diverse polycycles was identified in sp. DHS-48....
3.
Zhang K, Nie Q, Li M, Chen X, Zhong L, Dai T, et al.
Nucleic Acids Res . 2025 Jan; 53(3). PMID: 39883012
RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes...
4.
Ning K, Tang X, Li Z, Zhong L, Zhou Y, Wang J, et al.
Adv Sci (Weinh) . 2024 Dec; 12(8):e2413368. PMID: 39737862
DNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase...
5.
Xu S, Liu X, Wang L, Huang W, Hu Y, Chen S, et al.
Biochim Biophys Acta Mol Basis Dis . 2024 Dec; 1871(3):167630. PMID: 39675530
Background: The heat shock response (HSR) is a highly conserved mechanism that maintains intracellular homeostasis in response to various environmental and physiological stresses. Heat shock proteins (HSPs), particularly HSP70, play...
6.
Guo S, Hu Y, Rao Y, Jiang Z, Li C, Lin Y, et al.
Diabetes Obes Metab . 2024 Nov; 27(2):606-618. PMID: 39529440
Aims: Obesity always leads to profound perturbation of metabolome. Metabolome studies enrich the knowledge on associations between endogenous metabolites and obesity, potentially providing innovative strategies for the development of novel...
7.
Zhong L, Yuan J, Fu W, Zhang Z, Li X, Ou T, et al.
Bioorg Chem . 2024 Sep; 153:107842. PMID: 39342890
c-MYC is a proto-oncogene ubiquitously overexpressed in various cancers. The formation of G-quadruplex (G4) structures within the c-MYC promoter region can regulate its transcription by interfering with protein binding. Consequently,...
8.
Hu Y, Lin Y, Guo S, Jiang Z, Xu S, Su Z, et al.
Cell Signal . 2024 Sep; 124:111431. PMID: 39312987
The biological function against obesity of heat shock protein Hsp72 in adipose tissue has remained unclear. Our findings demonstrated that the expression levels of Hsp72 increased during the triglyceride (TG)...
9.
Wei L, Lin Y, Luo J, Li Y, Hu Y, Guo S, et al.
Eur J Med Chem . 2024 Aug; 277:116773. PMID: 39163779
Due to the emerging global epidemic of obesity, developing safe and effective agents for anti-obesity is urgently needed. Our previous study found that 2-pyrimidinylindole derivative Wd3d exhibited potential anti-obesity activity....
10.
Jiang Z, Hu Y, Guo S, Li Y, Zhao D, Wei L, et al.
J Med Chem . 2024 Jul; 67(14):12439-12458. PMID: 38996004
The discovery of effective and safe antiobesity agents remains a challenging yet promising field. Our previous studies identified Bouchardatine derivatives as potential antiobesity agents. However, the 8a-aldehyde moiety rendered them...