Jin-Ichi Inokuchi
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Explore the profile of Jin-Ichi Inokuchi including associated specialties, affiliations and a list of published articles.
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91
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1136
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Recent Articles
1.
Inamori K, Nakamura K, Shishido F, Hsu J, Nagafuku M, Nitta T, et al.
Front Neurosci
. 2024 Aug;
18:1437668.
PMID: 39145292
Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurological disorders that are characterized by progressive spasticity and weakness in the lower limbs. SPG26 is a complicated form of HSP,...
2.
Inokuchi J, Go S, Suzuki A, Nakagawasai O, Odaira-Satoh T, Veillon L, et al.
Front Neurosci
. 2024 Aug;
18:1387221.
PMID: 39119456
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the...
3.
Anan G, Nitta T, Kanoh H, Sato M, Inokuchi J
Transl Androl Urol
. 2024 Feb;
13(1):104-108.
PMID: 38404559
Benign prostatic hyperplasia (BPH) progresses with age and is associated with chronic inflammation. We focused on the relationship between BPH and ganglioside monosialodihexosylganglioside (GM3), a sialic acid-containing glycosphingolipid that is...
4.
Aoki E, Manabe N, Ohno S, Aoki T, Furukawa J, Togayachi A, et al.
Mol Genet Metab Rep
. 2023 Dec;
37:101016.
PMID: 38053926
Rare diseases are estimated to affect 3.5%-5.9% of the population worldwide and are difficult to diagnose. Genome analysis is useful for diagnosis. However, since some variants, especially missense variants, are...
5.
Takeda K, Kaifu T, Michihata R, Kinugawa N, Fujioka A, Tateno A, et al.
Eur J Immunol
. 2023 Aug;
53(10):e2350452.
PMID: 37565654
Theiler's murine encephalomyelitis virus (TMEV) causes a chronic demyelinating disease similar to multiple sclerosis in mice. Although sialic acids have been shown to be essential for TMEV attachment to the...
6.
Murate M, Yokoyama N, Tomishige N, Richert L, Humbert N, Pollet B, et al.
Cell Mol Life Sci
. 2023 May;
80(6):167.
PMID: 37249637
Monosialoganglioside GM3 is the simplest ganglioside involved in various cellular signaling. Cell surface distribution of GM3 is thought to be crucial for the function of GM3, but little is known...
7.
Watanabe S, Lei M, Nakagawa E, Takeshita E, Inamori K, Shishido F, et al.
Brain Dev
. 2023 Jan;
45(5):270-277.
PMID: 36690566
Background: ST3GAL5 encodes GM3 synthase (ST3 beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL5), which synthesizes GM3 by transferring sialic acid to lactosylceramide. GM3, a sialic acid-containing glycosphingolipid known as ganglioside, is a precursor...
8.
Suzuki A, Silsirivanit A, Watanabe T, Matsuda J, Inamori K, Inokuchi J
Methods Mol Biol
. 2022 Dec;
2613:127-144.
PMID: 36587076
This chapter describes the protocols for mass spectrometry (MS) applied to the structural characterization of neutral glycosphingolipids (GSLs) and the determination of neutral GSL contents in biological materials. The structural...
9.
Inamori K, Nitta T, Shishido F, Watanabe S, Ohno I, Inokuchi J
Methods Mol Biol
. 2022 Dec;
2613:101-110.
PMID: 36587074
GM3 synthase (GM3S) is a sialyltransferase that transfers sialic acid from CMP-sialic acid to lactosylceramide. This reaction results in formation of ganglioside GM3 and is essential for biosynthesis of its...
10.
Bharathi S, Zhang B, Paul E, Zhang Y, Schmidt A, Fowler B, et al.
Mol Genet Metab
. 2022 Nov;
137(4):342-348.
PMID: 36335793
GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder caused by an inability to synthesize gangliosides, for which there is currently no treatment. Gangliosides are brain-enriched, plasma membrane glycosphingolipids with...