Masakazu Nagafuku
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Explore the profile of Masakazu Nagafuku including associated specialties, affiliations and a list of published articles.
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27
Citations
746
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Recent Articles
1.
Inamori K, Nakamura K, Shishido F, Hsu J, Nagafuku M, Nitta T, et al.
Front Neurosci
. 2024 Aug;
18:1437668.
PMID: 39145292
Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurological disorders that are characterized by progressive spasticity and weakness in the lower limbs. SPG26 is a complicated form of HSP,...
2.
Inokuchi J, Nagafuku M
Glycoconj J
. 2022 Feb;
39(2):229-238.
PMID: 35156158
The molecular diversity of glycosphingolipids (GSLs) that arouse during the course of evolution clearly plays an essential role in maintenance of biological homeostasis. Why is such a wide variety of...
3.
Inokuchi J, Kanoh H, Inamori K, Nagafuku M, Nitta T, Fukase K
FEBS J
. 2021 Jun;
289(17):5152-5165.
PMID: 34125497
Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex gangliosides. The efforts of our research group since then...
4.
Toshima K, Nagafuku M, Okazaki T, Kobayashi T, Inokuchi J
Int Immunol
. 2018 Dec;
31(4):211-223.
PMID: 30561621
Sphingomyelin (SM) in combination with cholesterol forms specialized membrane lipid microdomains in which specific receptors and signaling molecules are localized or recruited to mediate intracellular signaling. SM-microdomain levels in mouse...
5.
Nakayama H, Nagafuku M, Suzuki A, Iwabuchi K, Inokuchi J
FEBS Lett
. 2018 Oct;
592(23):3921-3942.
PMID: 30320884
Lipid rafts formed by glycosphingolipids (GSLs) on cellular membranes play important roles in innate and adaptive immunity. Lactosylceramide (LacCer) forms lipid rafts on plasma and granular membranes of human neutrophils....
6.
NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains
Nihei W, Nagafuku M, Hayamizu H, Odagiri Y, Tamura Y, Kikuchi Y, et al.
J Lipid Res
. 2018 Sep;
59(11):2181-2187.
PMID: 30242108
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease. Intestinal cholesterol...
7.
Inokuchi J, Inamori K, Kabayama K, Nagafuku M, Uemura S, Go S, et al.
Prog Mol Biol Transl Sci
. 2018 May;
156:151-195.
PMID: 29747813
Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been...
8.
Nagafuku M, Sato T, Sato S, Shimizu K, Taira T, Inokuchi J
Glycobiology
. 2014 Oct;
25(3):303-18.
PMID: 25303960
Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution...
9.
Inokuchi J, Nagafuku M, Ohno I, Suzuki A
Biochim Biophys Acta
. 2014 Sep;
1851(1):98-106.
PMID: 25193136
T cells compose a crucial part of the immune system and require activation. The first step of T cell activation is triggered by the movement of one of their surface...
10.
Sato T, Nihei Y, Nagafuku M, Tagami S, Chin R, Kawamura M, et al.
Obes Res Clin Pract
. 2013 Dec;
2(4):I-II.
PMID: 24351849
Summary: Background: Insulin resistance is a characteristic feature of metabolic syndrome. Ganglioside GM3 [α-Neu5Ac-(2-3)-β-Gal-(1-4)-β-Glc-(1-1)-ceramide] may impair insulin sensitivity in adipose tissue. We investigated the relationship between serum GM3 levels and...