Jessica K Nelson
Overview
Explore the profile of Jessica K Nelson including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
254
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Recent Articles
1.
Nelson J, Zaw Thin M, Evan T, Howell S, Wu M, Almeida B, et al.
Nat Commun
. 2022 Apr;
13(1):2070.
PMID: 35440539
Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in pancreatic ductal adenocarcinoma (PDAC) has not...
2.
Khan O, Almagro J, Nelson J, Horswell S, Encheva V, Keyan K, et al.
Nat Commun
. 2021 Apr;
12(1):2043.
PMID: 33824312
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein...
3.
van Loon N, van Wouw S, Ottenhoff R, Nelson J, Kingma J, Scheij S, et al.
Atherosclerosis
. 2020 Nov;
315:1-9.
PMID: 33190106
Background And Aims: Cholesterol metabolism is tightly regulated by transcriptional and post-transcriptional mechanisms. Accordingly, dysregulation of cholesterol metabolism is a major risk factor for the development of coronary artery disease...
4.
Josue Ruiz E, Diefenbacher M, Nelson J, Sancho R, Pucci F, Chakraborty A, et al.
J Exp Med
. 2019 Jan;
216(2):450-465.
PMID: 30642944
Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The...
5.
Cook E, Nelson J, Sorrentino V, Koenis D, Moeton M, Scheij S, et al.
PLoS One
. 2017 Feb;
12(2):e0172721.
PMID: 28231341
Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver X Receptors (LXRs) play an important role owing to...
6.
Loregger A, Nelson J, Zelcer N
Methods Mol Biol
. 2017 Feb;
1583:53-63.
PMID: 28205166
Determination of LDL particle uptake into cells is a valuable technique in the field of cholesterol metabolism. This allows assessment of LDL uptake capacity in different adherent and non-adherent cells...
7.
Marques A, Willems L, Moro D, Florea B, Scheij S, Ottenhoff R, et al.
Chembiochem
. 2016 Dec;
18(4):402-412.
PMID: 28000364
Galactosylceramidase (GALC) is the lysosomal β-galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe disease, a devastating neurological disorder characterized by accumulation of galactosylceramide and its...
8.
Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism
Lu X, Meima M, Nelson J, Sorrentino V, Loregger A, Scheij S, et al.
Circ Res
. 2015 Nov;
118(2):222-9.
PMID: 26582775
Rationale: The (pro)renin receptor ([P]RR) interacts with (pro)renin at concentrations that are >1000× higher than observed under (patho)physiological conditions. Recent studies have identified renin-angiotensin system-independent functions for (P)RR related to...
9.
Sorrentino V, Nelson J, Maspero E, Marques A, Scheer L, Polo S, et al.
J Lipid Res
. 2013 Jun;
54(8):2174-2184.
PMID: 23733886
Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas...
10.
Sorrentino V, Fouchier S, Motazacker M, Nelson J, Defesche J, Dallinga-Thie G, et al.
Eur Heart J
. 2013 Jan;
34(17):1292-7.
PMID: 23324548
Aims: Recent genome-wide association studies suggest that IDOL (also known as MYLIP) contributes to variation in circulating levels of low-density lipoprotein cholesterol (LDL-C). IDOL, an E3-ubiquitin ligase, is a recently...