Anke Loregger
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Explore the profile of Anke Loregger including associated specialties, affiliations and a list of published articles.
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Citations
327
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Recent Articles
1.
Song B, Liu D, Dai W, McMyn N, Wang Q, Yang D, et al.
Nat Cell Biol
. 2025 Feb;
27(3):493-504.
PMID: 40011559
Understanding how cells respond differently to perturbation is crucial in cell biology, but existing methods often fail to accurately quantify and interpret heterogeneous single-cell responses. Here we introduce the perturbation-response...
2.
Hendrix S, Tan J, Ndoj K, Kingma J, Valiloo M, Zijlstra L, et al.
Mol Cell Biol
. 2024 May;
44(4):123-137.
PMID: 38747374
SREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent cleavage by site-1-protease (S1P). Produced as a proprotein, S1P undergoes...
3.
Song B, Liu D, Dai W, McMyn N, Wang Q, Yang D, et al.
bioRxiv
. 2023 Nov;
PMID: 37961332
Understanding diverse responses of individual cells to the same perturbation is central to many biological and biomedical problems. Current methods, however, do not precisely quantify the strength of perturbation responses...
4.
Hendrix S, Kingma J, Ottenhoff R, Valiloo M, Svecla M, Zijlstra L, et al.
Nat Commun
. 2023 Aug;
14(1):5181.
PMID: 37626055
The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post-transcriptional regulator of SREBP activation. Constitutive or...
5.
Tan J, van der Stoel M, van den Berg M, van Loon N, Moeton M, Scholl E, et al.
Cell Rep
. 2020 Aug;
32(5):107944.
PMID: 32755570
The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is...
6.
Loregger A, Raaben M, Nieuwenhuis J, Tan J, Jae L, van den Hengel L, et al.
Nat Commun
. 2020 Mar;
11(1):1128.
PMID: 32111832
The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify the SREBP Regulating Gene (SPRING/C12ORF49) as a determinant of the SREBP...
7.
Oteng A, Loregger A, van Weeghel M, Zelcer N, Kersten S
Mol Nutr Food Res
. 2019 Jul;
63(19):e1900385.
PMID: 31327168
Scope: The mechanisms underlying the deleterious effects of trans fatty acids on plasma cholesterol and non-alcoholic fatty liver disease (NAFLD) are unclear. Here, the aim is to investigate the molecular...
8.
van den Boogert M, Larsen L, Ali L, Kuil S, Chong P, Loregger A, et al.
Circulation
. 2019 May;
140(4):280-292.
PMID: 31117816
Background: The importance of protein glycosylation in regulating lipid metabolism is becoming increasingly apparent. We set out to further investigate this by studying patients with type I congenital disorders of...
9.
Tan J, Cook E, van den Berg M, Scheij S, Zelcer N, Loregger A
Atherosclerosis
. 2019 Jan;
281:137-142.
PMID: 30658189
Background And Aims: Cholesterol is an essential lipid for cellular function and membrane integrity, and hence its cellular levels and distribution must be tightly regulated. Biosynthesis of cholesterol is ramped...
10.
Pronk M, Majolee J, Loregger A, van Bezu J, Zelcer N, Hordijk P, et al.
Mol Biol Cell
. 2019 Jan;
30(5):607-621.
PMID: 30601691
Rho GTPases control both the actin cytoskeleton and adherens junction stability and are recognized as essential regulators of endothelial barrier function. They act as molecular switches and are primarily regulated...