Ambrosius P Snijders
Overview
Explore the profile of Ambrosius P Snijders including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
5767
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Recent Articles
1.
OSullivan P, Aidarova A, Afonina I, Manils J, Thurston T, Instrell R, et al.
Biochem J
. 2024 Aug;
481(18):1143-1171.
PMID: 39145956
Rare mutations in CARD14 promote psoriasis by inducing CARD14-BCL10-MALT1 complexes that activate NF-κB and MAP kinases. Here, the downstream signalling mechanism of the highly penetrant CARD14E138A alteration is described. In...
2.
Lukauskas S, Tvardovskiy A, Nguyen N, Stadler M, Faull P, Ravnsborg T, et al.
Nature
. 2024 Apr;
628(8009):E6.
PMID: 38594341
No abstract available.
3.
Pearson G, Mears H, Broncel M, Snijders A, Bauer D, Carlton J
Sci Adv
. 2024 Apr;
10(14):eadl5012.
PMID: 38569033
The β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the global COVID-19 pandemic. Coronaviral Envelope (E) proteins are pentameric viroporins that play essential roles in...
4.
Lukauskas S, Tvardovskiy A, Nguyen N, Stadler M, Faull P, Ravnsborg T, et al.
Nature
. 2024 Mar;
627(8004):671-679.
PMID: 38448585
DNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome. While many 'readers' of individual modifications have been described, how chromatin states comprising composite modification...
5.
Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, et al.
Sci Transl Med
. 2024 Jan;
16(731):eadd6883.
PMID: 38266108
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene dosage disorder that results in multiple phenotypes including congenital heart defects. This clinically important...
6.
Henry C, Castellanos C, Buck M, Giampazolias E, Frederico B, Cardoso A, et al.
Cell Rep
. 2023 Nov;
42(12):113506.
PMID: 38019655
Cross-presentation of dead cell-associated antigens by conventional dendritic cells type 1 (cDC1s) is critical for CD8 T cells response against many tumors and viral infections. It is facilitated by DNGR-1...
7.
Fisch D, Pfleiderer M, Anastasakou E, Mackie G, Wendt F, Liu X, et al.
Science
. 2023 Oct;
382(6666):eadg2253.
PMID: 37797010
Disruption of cellular activities by pathogen virulence factors can trigger innate immune responses. Interferon-γ (IFN-γ)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular...
8.
Mihaylov S, Castelli L, Lin Y, Gul A, Soni N, Hastings C, et al.
Nat Commun
. 2023 Sep;
14(1):5496.
PMID: 37679383
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a...
9.
Ensinck I, Maman A, Albihlal W, Lassandro M, Salzano G, Sideri T, et al.
Elife
. 2023 Jul;
12.
PMID: 37490041
-methyladenosine (m6A), the most abundant mRNA modification, is deposited in mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic subunit and at least five additional proteins. The yeast MTC is...
10.
Ramaprasad A, Burda P, Koussis K, Thomas J, Pietsch E, Calvani E, et al.
PLoS Pathog
. 2023 Jun;
19(6):e1011449.
PMID: 37352369
Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim...