Jerome Mertens
Overview
Explore the profile of Jerome Mertens including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
3270
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Recent Articles
1.
Eichhorner S, Traxler L, Borgogno O, Mertens J
Cell Stem Cell
. 2024 Nov;
31(11):1551-1552.
PMID: 39515295
Studies from Ionescu et al. and Clayton et al. using multiple sclerosis (MS) patient-derived cell models underscore cholesterol metabolism's role in inflammatory and dysfunctional cell phenotypes in the disease. Inhibiting...
2.
Herdy J, Mertens J, Gage F
Science
. 2024 Jun;
384(6703):1404-1406.
PMID: 38935713
Senescence of postmitotic neurons presents challenges and opportunities to modify brain aging.
3.
Spathopoulou A, Sauerwein G, Marteau V, Podlesnic M, Lindlbauer T, Kipura T, et al.
Mol Psychiatry
. 2024 Apr;
29(10):3128-3140.
PMID: 38684795
Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains elusive although it is hypothesized to be associated with...
4.
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, et al.
Cell Metab
. 2024 Apr;
36(6):1351-1370.e8.
PMID: 38657612
The accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is considered a pathological phenomenon with unresolved cellular and molecular mechanisms. Utilizing stimulated Raman scattering (SRS) microscopy, we...
5.
Traxler L, Borgogno O, Mertens J
Neuron
. 2024 Apr;
112(7):1035-1037.
PMID: 38574725
Direct conversion of non-neuronal cells to neurons offers opportunities for disease modeling and therapy. In this issue of Neuron, Sonsalla et al. reveal the unfolded protein response (UPR) pathway as...
6.
Pitrez P, Monteiro L, Borgogno O, Nissan X, Mertens J, Ferreira L
Nat Commun
. 2024 Feb;
15(1):1816.
PMID: 38418829
The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span....
7.
Castillo Bautista C, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters H, et al.
Cells
. 2023 Sep;
12(18).
PMID: 37759469
Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons against...
8.
Traxler L, Lucciola R, Herdy J, Jones J, Mertens J, Gage F
Nat Rev Neurol
. 2023 Jun;
19(7):434-443.
PMID: 37268723
Most age-related neurodegenerative diseases remain incurable owing to an incomplete understanding of the disease mechanisms. Several environmental and genetic factors contribute to disease onset, with human biological ageing being the...
9.
de la Fuente A, Pelucchi S, Mertens J, Di Luca M, Mauceri D, Marcello E
Br J Pharmacol
. 2023 Mar;
180(13):1651-1673.
PMID: 36965025
Ageing is the main risk factor common to most primary neurodegenerative disorders. Indeed, age-related brain alterations have been long considered to predispose to neurodegeneration. Although protein misfolding and the accumulation...
10.
Herdy J, Traxler L, Agarwal R, Karbacher L, Schlachetzki J, Boehnke L, et al.
Cell Stem Cell
. 2022 Dec;
29(12):1637-1652.e6.
PMID: 36459967
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent...