Cellular Reprogramming As a Tool to Model Human Aging in a Dish

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Feb 28

PMID 38418829

Authors

Patricia R Pitrez

Luis M Monteiro

Oliver Borgogno

Xavier Nissan

Jerome Mertens

Lino Ferreira

Affiliations

Soon will be listed here.

Abstract

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

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