Jeremy Setton
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Explore the profile of Jeremy Setton including associated specialties, affiliations and a list of published articles.
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34
Citations
945
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Recent Articles
1.
Zhu Y, Pei X, Novaj A, Setton J, Bronder D, Derakhshan F, et al.
Genome Med
. 2024 Aug;
16(1):108.
PMID: 39198848
Background: Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cellular...
2.
Ng V, Sinha S, Novaj A, Ma J, McDermott N, Pei X, et al.
Clin Cancer Res
. 2024 Aug;
30(24):5643-5656.
PMID: 39109923
Purpose: The importance of the DNA damage response in mediating effects of radiotherapy (RT) has galvanized efforts to target this pathway with radiosensitizers. Yet early clinical trials of this approach...
3.
Ma J, Shah R, Bell A, McDermott N, Pei X, Selenica P, et al.
Int J Radiat Oncol Biol Phys
. 2024 Jul;
121(3):768-779.
PMID: 38997095
Purpose: Homologous recombination deficient (HRD) tumors are exquisitely sensitive to platinum-based chemotherapy and when combined with radiation therapy (RT), leads to improved overall survival in multiple cancer types. Whether a...
4.
Choo Z, Behr J, Deshpande A, Hadi K, Yao X, Tian H, et al.
Nat Genet
. 2023 Nov;
55(12):2139-2148.
PMID: 37945902
Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many structural variants (SVs), particularly large chromosomal alterations. To characterize missing SVs in short-read whole genomes, we...
5.
Setton J, Hadi K, Choo Z, Kuchin K, Tian H, Da Cruz Paula A, et al.
Nature
. 2023 Aug;
621(7977):129-137.
PMID: 37587346
Homologous recombination (HR) deficiency is associated with DNA rearrangements and cytogenetic aberrations. Paradoxically, the types of DNA rearrangements that are specifically associated with HR-deficient cancers only minimally affect chromosomal structure....
6.
Setton J, Selenica P, Mukherjee S, Shah R, Pecorari I, McMillan B, et al.
NPJ Breast Cancer
. 2021 Oct;
7(1):135.
PMID: 34635660
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting...
7.
Samstein R, Krishna C, Ma X, Pei X, Lee K, Makarov V, et al.
Nat Cancer
. 2021 Apr;
1(12):1188-1203.
PMID: 33834176
Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. Here we report differential effects of mutations in the homologous...
8.
Setton J, Zinda M, Riaz N, Durocher D, Zimmermann M, Koehler M, et al.
Cancer Discov
. 2021 Apr;
11(7):1626-1635.
PMID: 33795234
Synthetic lethality (SL) provides a conceptual framework for tackling targets that are not classically "druggable," including loss-of-function mutations in tumor suppressor genes required for carcinogenesis. Recent technological advances have led...
9.
Setton J, Reis-Filho J, Powell S
Curr Opin Genet Dev
. 2021 Jan;
66:93-100.
PMID: 33477018
Cancer genomes harbor mutational and structural rearrangements that are jointly shaped by DNA damage and repair mechanisms. Accumulating evidence suggests that genetic alterations in DNA repair-defective tumors reflect the scars...
10.
Hadi K, Yao X, Behr J, Deshpande A, Xanthopoulakis C, Tian H, et al.
Cell
. 2020 Oct;
183(1):197-210.e32.
PMID: 33007263
Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be easily classified into simple (e.g., deletion) or complex (e.g., chromothripsis) structural variant classes. Applying a...