Simon N Powell
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Explore the profile of Simon N Powell including associated specialties, affiliations and a list of published articles.
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174
Citations
6695
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Recent Articles
1.
Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, et al.
bioRxiv
. 2025 Mar;
PMID: 40060534
Double-strand breaks (DSBs) are toxic lesions that lead to genome instability. While canonical DSB repair pathways typically operate independently of RNA, emerging evidence suggests that RNA:DNA hybrids and transcripts near...
2.
Taghian A, Naoum G, Braunstein L, Niemierko A, Smith B, Gadd M, et al.
Int J Radiat Oncol Biol Phys
. 2025 Jan;
121(4):900-909.
PMID: 39797875
Purpose: Randomized trials have demonstrated similar local tumor control in patients treated with accelerated partial-breast irradiation (APBI) compared with whole-breast irradiation. However, the optimal APBI dose for maximizing tumor control...
3.
Braunstein L, Boe L, Mueller B, Roth OBrien D, Choi I, Cuaron J, et al.
Int J Radiat Oncol Biol Phys
. 2024 Oct;
121(4):894-899.
PMID: 39461598
Purpose: Invasive lobular carcinoma (ILC) represents 10% to 15% of invasive breast cancers with limited representation among trials of accelerated partial breast irradiation (APBI). Contemporary guidelines advise against treating ILC...
4.
Yu A, White C, Zhang Z, Liu J, Gillespie E, McCormick B, et al.
Adv Radiat Oncol
. 2024 Sep;
9(10):101581.
PMID: 39258142
Purpose: Regional nodal irradiation (RNI) for breast cancer yields improvements in disease outcomes, yet comprehensive target coverage often increases cardiac radiation therapy (RT) dose. Volumetric modulated arc therapy (VMAT) may...
5.
Mathieu M, Nepali P, Russell J, Askarifirouzjaei H, Baltaci M, Powell S, et al.
Cell Physiol Biochem
. 2024 Sep;
58(5):477-490.
PMID: 39248192
Background/aims: Tumor response to radiation is thought to depend on the direct killing of tumor cells. Our laboratory has called this into question. Firstly, we showed that the biology of...
6.
Jalan M, Sharma A, Pei X, Weinhold N, Buechelmaier E, Zhu Y, et al.
Nat Commun
. 2024 Sep;
15(1):7776.
PMID: 39237529
Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of...
7.
Zhu Y, Pei X, Novaj A, Setton J, Bronder D, Derakhshan F, et al.
Genome Med
. 2024 Aug;
16(1):108.
PMID: 39198848
Background: Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cellular...
8.
Ng V, Sinha S, Novaj A, Ma J, McDermott N, Pei X, et al.
Clin Cancer Res
. 2024 Aug;
30(24):5643-5656.
PMID: 39109923
Purpose: The importance of the DNA damage response in mediating effects of radiotherapy (RT) has galvanized efforts to target this pathway with radiosensitizers. Yet early clinical trials of this approach...
9.
Ma J, Shah R, Bell A, McDermott N, Pei X, Selenica P, et al.
Int J Radiat Oncol Biol Phys
. 2024 Jul;
121(3):768-779.
PMID: 38997095
Purpose: Homologous recombination deficient (HRD) tumors are exquisitely sensitive to platinum-based chemotherapy and when combined with radiation therapy (RT), leads to improved overall survival in multiple cancer types. Whether a...
10.
McMillan M, Khan A, Powell S, Humm J, Deasy J, Haimovitz-Friedman A
Semin Radiat Oncol
. 2024 Jun;
34(3):276-283.
PMID: 38880536
Spatially fractionated radiotherapy (SFRT) includes historical grid therapy approaches but more recently encompasses the controlled introduction of one or more cold dose regions using intensity modulation delivery techniques. The driving...