Paul D Robbins
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Explore the profile of Paul D Robbins including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Dan X, Croteau D, Liu W, Chu X, Robbins P, Bohr V
bioRxiv
. 2025 Mar;
PMID: 40027687
Dysfunctional mitophagy is a key component of Alzheimer's disease (AD) pathology, yet direct evidence and mechanistic insights remain limited. Using a mitophagy reporter in an AD mouse model ( /...
2.
Mahmud S, Zheng C, Santiago F, Zhang L, Robbins P, Dong X
Geroscience
. 2024 Dec;
PMID: 39738795
Although cellular senescence has been recognized as a hallmark of aging, it is challenging to detect senescence cells (SnCs) due to their high level of heterogeneity at the molecular level....
3.
Reader B, Rosas L, Knopf B, Liu Y, Alzate-Correa D, Bhat A, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Dec;
80(2).
PMID: 39704343
As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of...
4.
Narasimhan A, Min S, Johnson L, Roehrich H, Cho W, Her T, et al.
Aging Cell
. 2024 Nov;
24(3):e14419.
PMID: 39604117
Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest...
5.
Kim J, Buffenstein R, Bronikowski A, Pilar Vanegas N, Rosas L, Agudelo-Garcia P, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Nov;
79(11).
PMID: 39498863
The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence of age-related diseases....
6.
Zhang L, Salekeen R, Soto-Palma C, Elsallabi O, Ye H, Hughes B, et al.
bioRxiv
. 2024 Oct;
PMID: 39463954
Cellular senescence is a key driver of the aging process and contributes to tissue dysfunction and age-related pathologies. Senolytics have emerged as a promising therapeutic intervention to extend healthspan and...
7.
Lyu Y, Fu Q, Wilczok D, Ying K, King A, Antebi A, et al.
Aging (Albany NY)
. 2024 Oct;
16(20):12955-12976.
PMID: 39418098
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We,...
8.
Monroe T, Hertzel A, Dickey D, Hagen T, Santibanez S, Berdaweel I, et al.
Aging Cell
. 2024 Oct;
24(1):e14367.
PMID: 39394673
Lipid enals are electrophilic products of lipid peroxidation that induce genotoxic and proteotoxic stress by covalent modification of DNA and proteins, respectively. As lipid enals accumulate to substantial amounts in...
9.
Carey A, Pitcher L, Jang I, Nguyen K, Cholensky S, Robbins P, et al.
J Leukoc Biol
. 2024 Oct;
117(2).
PMID: 39378334
Myeloid cell production of interleukin-1β (IL-1β) drives inflammaging in visceral white adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1)-positive aged adipose B cells (AABs). AABs...
10.
Santiago F, Adige T, Mahmud S, Dong X, Niedernhofer L, Robbins P
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2321182121.
PMID: 39325426
Senescence is a cell fate driven by different types of stress that results in exit from the cell cycle and expression of an inflammatory senescence-associated secretory phenotype (SASP). Here, we...