Jennifer G Aparicio
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Explore the profile of Jennifer G Aparicio including associated specialties, affiliations and a list of published articles.
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14
Citations
356
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Recent Articles
1.
Shayler D, Stachelek K, Cambier L, Lee S, Bai J, Reid M, et al.
bioRxiv
. 2024 Jun;
PMID: 38915659
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing...
2.
Bai J, Koos D, Stepanian K, Fouladian Z, Shayler D, Aparicio J, et al.
Dis Model Mech
. 2023 Oct;
16(11).
PMID: 37902188
Fluorescent reporter pluripotent stem cell-derived retinal organoids are powerful tools to investigate cell type-specific development and disease phenotypes. When combined with live imaging, they enable direct and repeated observation of...
3.
Aparicio J, Hopp H, Harutyunyan N, Stewart C, Cobrinik D, Borchert M
Ophthalmic Genet
. 2023 Oct;
45(1):1-15.
PMID: 37807874
Background: Optic nerve hypoplasia (ONH), the leading congenital cause of permanent blindness, is characterized by a retinal ganglion cell (RGC) deficit at birth. Multifactorial developmental events are hypothesized to underlie...
4.
Bai J, Koos D, Stepanian K, Fouladian Z, Shayler D, Aparicio J, et al.
bioRxiv
. 2023 Mar;
PMID: 36909527
Fluorescent reporter pluripotent stem cell (PSC) derived retinal organoids are powerful tools to investigate cell type-specific development and disease phenotypes. When combined with live imaging, they enable direct and repeated...
5.
Stachelek K, Harutyunyan N, Lee S, Beck A, Kim J, Xu L, et al.
Genes Chromosomes Cancer
. 2022 Dec;
62(5):275-289.
PMID: 36550020
Retinoblastomas form in response to biallelic RB1 mutations or MYCN amplification and progress to more aggressive and therapy-resistant phenotypes through accumulation of secondary genomic changes. Progression-related changes include recurrent somatic...
6.
Prameela Bharathan S, Ferrario A, Stepanian K, Fernandez G, Reid M, Kim J, et al.
Development
. 2021 Nov;
148(23).
PMID: 34738615
The development of the first synapse of the visual system between photoreceptors and bipolar cells in the outer plexiform layer (OPL) of the human retina is crucial for visual processing...
7.
Browne A, Arnesano C, Harutyunyan N, Khuu T, Martinez J, Pollack H, et al.
Invest Ophthalmol Vis Sci
. 2017 Jul;
58(9):3311-3318.
PMID: 28672397
Purpose: Human pluripotent stem cell (hPSC)-derived retinal organoids are a platform for investigating retinal development, pathophysiology, and cellular therapies. In contrast to histologic analysis in which multiple specimens fixed at...
8.
Li W, Buckley J, Sanchez-Lara P, Maglinte D, Viduetsky L, Tatarinova T, et al.
J Mol Diagn
. 2016 May;
18(4):480-93.
PMID: 27155049
Retinoblastoma is a childhood eye malignancy that can lead to the loss of vision, eye(s), and sometimes life. The tumors are initiated by inactivating mutations in both alleles of the...
9.
Ostrow A, Viggiani C, Aparicio J, Aparicio O
Methods Mol Biol
. 2015 Apr;
1300:155-68.
PMID: 25916712
Chromatin immunoprecipitation (ChIP) is a widely used method to study interactions between proteins and discrete chromosomal loci in vivo. ChIP was originally developed for in vivo analysis of protein associations...
10.
Viggiani C, Aparicio J, Aparicio O
Methods Mol Biol
. 2009 Jul;
521:255-78.
PMID: 19563111
Chromatin immunoprecipitation (ChIP) is a widely used method to study the interactions between proteins and discrete chromosomal loci in vivo. Originally, ChIP was developed for analysis of protein associations with...