Jeffrey R Gulcher
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Explore the profile of Jeffrey R Gulcher including associated specialties, affiliations and a list of published articles.
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79
Citations
16666
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Recent Articles
1.
Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, et al.
Sci Transl Med
. 2021 Oct;
14(628):eabj7521.
PMID: 34698500
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators of this condition have remained elusive. We used a...
2.
Li R, Gujja S, Bajaj S, Gamel O, Cilfone N, Gulcher J, et al.
Patterns (N Y)
. 2021 Jun;
2(6):100246.
PMID: 34179840
Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex molecular underpinnings of human disease from a genome-wide...
3.
Simons M, Gulcher J, Chittenden T
Aging (Albany NY)
. 2020 Jun;
12(11):10001-10003.
PMID: 32530820
No abstract available.
4.
Chen P, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, et al.
Cell Stem Cell
. 2020 Apr;
26(4):542-557.e11.
PMID: 32243809
The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the...
5.
Li G, Wang M, Caulk A, Cilfone N, Gujja S, Qin L, et al.
J Clin Invest
. 2020 Feb;
130(3):1233-1251.
PMID: 32039915
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated...
6.
Ricard N, Scott R, Booth C, Velazquez H, Cilfone N, Baylon J, et al.
J Exp Med
. 2019 Jun;
216(8):1874-1890.
PMID: 31196980
To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial knockout in adult mice. This resulted in a rapid onset of hypertension, a decrease in eNOS...
7.
Baylon J, Cilfone N, Gulcher J, Chittenden T
J Chem Inf Model
. 2019 Jan;
59(2):673-688.
PMID: 30642173
Chemical synthesis planning is a key aspect in many fields of chemistry, especially drug discovery. Recent implementations of machine learning and artificial intelligence techniques for retrosynthetic analysis have shown great...
8.
Gudmundsson J, Sulem P, Gudbjartsson D, Masson G, Agnarsson B, Benediktsdottir K, et al.
Nat Genet
. 2012 Oct;
44(12):1326-9.
PMID: 23104005
In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous...
9.
Gudmundsson J, Sulem P, Gudbjartsson D, Jonasson J, Masson G, He H, et al.
Nat Genet
. 2012 Jan;
44(3):319-22.
PMID: 22267200
To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study...
10.
Schunkert H, Konig I, Kathiresan S, Reilly M, Assimes T, Holm H, et al.
Nat Genet
. 2011 Mar;
43(4):333-8.
PMID: 21378990
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of...