Hreinn Stefansson
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Explore the profile of Hreinn Stefansson including associated specialties, affiliations and a list of published articles.
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30731
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Recent Articles
1.
OConnell K, Koromina M, van der Veen T, Boltz T, David F, Yang J, et al.
Nature
. 2025 Jan;
PMID: 39843750
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants...
2.
Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs
Koch E, Jurgenson T, Einarsson G, Mitchell B, Harder A, Garcia-Marin L, et al.
Res Sq
. 2025 Jan;
PMID: 39764137
Antidepressants exhibit a considerable variation in efficacy, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response. Here, we combined data on antidepressant non-response measured using rating scales...
3.
Kjaersgaard Andersen R, Stefansdottir L, Riis P, Halldorsson G, Ferkingstad E, Oddsson A, et al.
J Am Acad Dermatol
. 2024 Dec;
PMID: 39645042
Background: The contributions of genetic and environmental risk factors to hidradenitis suppurativa (HS) are both poorly understood. Objective: To identify sequence variants that associate with HS and determine the contribution...
4.
Braun A, Shekhar S, Levey D, Straub P, Kraft J, Panagiotaropoulou G, et al.
Nat Commun
. 2024 Nov;
15(1):9839.
PMID: 39537604
Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a...
5.
Einarsson G, Thorleifsson G, Steinthorsdottir V, Zink F, Helgason H, Olafsdottir T, et al.
Nat Commun
. 2024 Nov;
15(1):9335.
PMID: 39532837
Mendelian Randomization studies indicate that BMI contributes to various diseases, but it's unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence...
6.
Ivarsdottir E, Gudmundsson J, Tragante V, Sveinbjornsson G, Kristmundsdottir S, Stacey S, et al.
Nat Genet
. 2024 Oct;
56(11):2422-2433.
PMID: 39472694
Discovery of cancer risk variants in the sequence of the germline genome can shed light on carcinogenesis. Here we describe gene burden association analyses, aggregating rare missense and loss of...
7.
Strom N, Halvorsen M, Grove J, Asbjornsdottir B, Ludvigsson P, Thorarensen O, et al.
Biol Psychiatry
. 2024 Oct;
97(7):743-752.
PMID: 39389409
Background: Despite the significant personal and societal burden of tic disorders (TDs), treatment outcomes remain modest, necessitating a deeper understanding of their etiology. Family history is the biggest known risk...
8.
Worm J, Jorgensen I, Davidsson O, Hjalgrim H, Roder T, Ostrowski S, et al.
Pain
. 2024 Oct;
PMID: 39365662
There is a limited understanding of risk factors and comorbidities in trigeminal neuralgia, a disease characterized by paroxysms of severe unilateral facial pain and a higher incidence in women. We...
9.
Nudel R, Chrsitensen R, Kalnak N, Lundberg M, Schwinn M, Sorensen E, et al.
Psychiatry Res
. 2024 Sep;
342:116212.
PMID: 39348781
Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and...
10.
Oddsson A, Steinthorsdottir V, Oskarsson G, Styrkarsdottir U, Moore K, Isberg S, et al.
Nat Genet
. 2024 Aug;
56(9):1804-1810.
PMID: 39192094
Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS)...