Jason Stumpff
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Explore the profile of Jason Stumpff including associated specialties, affiliations and a list of published articles.
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42
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1109
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Recent Articles
11.
Sepaniac L, Martin W, Dionne L, Stearns T, Reinholdt L, Stumpff J
J Cell Biol
. 2021 Sep;
220(11).
PMID: 34515734
Micronuclei, whole or fragmented chromosomes spatially separated from the main nucleus, are associated with genomic instability and have been identified as drivers of tumorigenesis. Paradoxically, Kif18a mutant mice produce micronuclei...
12.
Marquis C, Fonseca C, Queen K, Wood L, Vandal S, Malaby H, et al.
Nat Commun
. 2021 Feb;
12(1):1213.
PMID: 33619254
Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells may respond differently...
13.
Cohen-Sharir Y, McFarland J, Abdusamad M, Marquis C, Bernhard S, Kazachkova M, et al.
Nature
. 2021 Jan;
590(7846):486-491.
PMID: 33505028
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells. Here we mapped the...
14.
Bodrug T, Wilson-Kubalek E, Nithianantham S, Thompson A, Alfieri A, Gaska I, et al.
Elife
. 2020 Jan;
9.
PMID: 31958056
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory...
15.
Fonseca C, Malaby H, Sepaniac L, Martin W, Byers C, Czechanski A, et al.
J Cell Biol
. 2019 Feb;
218(4):1148-1163.
PMID: 30733233
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood. Normal...
16.
Malaby H, Dumas M, Ohi R, Stumpff J
J Cell Biol
. 2019 Feb;
218(4):1218-1234.
PMID: 30709852
Mitotic kinesins must be regulated to ensure a precise balance of spindle forces and accurate segregation of chromosomes into daughter cells. Here, we demonstrate that kinesin-binding protein (KBP) reduces the...
17.
Malaby H, Lessard D, Berger C, Stumpff J
Life Sci Alliance
. 2019 Jan;
2(1).
PMID: 30655363
KIF18A (kinesin-8) is required for mammalian mitotic chromosome alignment. KIF18A confines chromosome movement to the mitotic spindle equator by accumulating at the plus-ends of kinetochore microtubule bundles (K-fibers), where it...
18.
Muretta J, Reddy B, Scarabelli G, Thompson A, Jariwala S, Major J, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(8):E1779-E1788.
PMID: 29432173
Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation...
19.
Tracy K, Tye C, Ghule P, Malaby H, Stumpff J, Stein J, et al.
Mol Cancer Res
. 2018 Jan;
16(4):587-598.
PMID: 29378907
Aggressive breast cancer is difficult to treat as it is unresponsive to many hormone-based therapies; therefore, it is imperative to identify novel, targetable regulators of progression. Long non-coding RNAs (lncRNA)...
20.
Zhou J, Chan J, Lambele M, Yusufzai T, Stumpff J, Opresko P, et al.
Cell Rep
. 2017 Aug;
20(9):2044-2056.
PMID: 28854357
Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss...