Heidi L H Malaby
Overview
Explore the profile of Heidi L H Malaby including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
312
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0
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Recent Articles
1.
Marquis C, Fonseca C, Queen K, Wood L, Vandal S, Malaby H, et al.
Nat Commun
. 2021 Feb;
12(1):1213.
PMID: 33619254
Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells may respond differently...
2.
Cohen-Sharir Y, McFarland J, Abdusamad M, Marquis C, Bernhard S, Kazachkova M, et al.
Nature
. 2021 Jan;
590(7846):486-491.
PMID: 33505028
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells. Here we mapped the...
3.
Fonseca C, Malaby H, Sepaniac L, Martin W, Byers C, Czechanski A, et al.
J Cell Biol
. 2019 Feb;
218(4):1148-1163.
PMID: 30733233
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood. Normal...
4.
Malaby H, Dumas M, Ohi R, Stumpff J
J Cell Biol
. 2019 Feb;
218(4):1218-1234.
PMID: 30709852
Mitotic kinesins must be regulated to ensure a precise balance of spindle forces and accurate segregation of chromosomes into daughter cells. Here, we demonstrate that kinesin-binding protein (KBP) reduces the...
5.
Tracy K, Tye C, Ghule P, Malaby H, Stumpff J, Stein J, et al.
Mol Cancer Res
. 2018 Jan;
16(4):587-598.
PMID: 29378907
Aggressive breast cancer is difficult to treat as it is unresponsive to many hormone-based therapies; therefore, it is imperative to identify novel, targetable regulators of progression. Long non-coding RNAs (lncRNA)...
6.
7.
Malaby H, Kobertz W
Biochemistry
. 2014 Jul;
53(30):4884-93.
PMID: 25029371
Asparagine (N)-linked glycosylation is essential for efficient protein folding in the endoplasmic reticulum (ER) and anterograde trafficking through the secretory pathway. N-Glycans are attached to nascent polypeptides at consensus sites,...
8.
Malaby H, Kobertz W
Biochem J
. 2013 May;
453(3):427-34.
PMID: 23718681
Type I transmembrane peptides acquire N-linked glycans during and after protein synthesis to facilitate anterograde trafficking through the secretory pathway. Mutations in N-glycosylation consensus sites (NXT and NXS, where X≠P)...