Jason Holt
Overview
Explore the profile of Jason Holt including associated specialties, affiliations and a list of published articles.
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11
Citations
110
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Recent Articles
1.
Rulent J, James M, Rameshwaran P, Jardine J, Katavouta A, Wakelin S, et al.
Mar Pollut Bull
. 2024 Oct;
209(Pt A):117129.
PMID: 39432987
The MV X-Press Pearl accident near Sri Lanka in May 2021 released several pollutants into the ocean, including 1843.3 t of urea, raising concerns about the impact on the region....
2.
Powley H, Polimene L, Torres R, Al Azhar M, Bell V, Cooper D, et al.
Sci Total Environ
. 2023 Nov;
912:168938.
PMID: 38029982
Terrigenous carbon in aquatic systems is increasingly recognised as an important part of the global carbon cycle. Despite this, the fate and distribution of terrigenous dissolved organic carbon (tDOC) in...
3.
Gorsuch C, Nemec P, Yu M, Xu S, Han D, Smith J, et al.
Mol Ther
. 2022 May;
30(9):2909-2922.
PMID: 35581938
Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all...
4.
Schulte C, Deaton D, Diaz E, Do Y, Gampe R, Guss J, et al.
Bioorg Med Chem Lett
. 2021 May;
47:128113.
PMID: 33991628
Through an internal virtual screen at GlaxoSmithKline a distinct class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors were discovered. Careful evaluation of crystal structures and SAR led to a novel, potent, and orally...
5.
Cadilla R, Deaton D, Do Y, Elkins P, Ennulat D, Guss J, et al.
Bioorg Med Chem
. 2020 Oct;
28(23):115791.
PMID: 33059303
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals....
6.
Deaton D, Do Y, Holt J, Jeune M, Kramer H, Larkin A, et al.
Bioorg Med Chem
. 2019 Mar;
27(8):1456-1478.
PMID: 30858025
With the goal of discovering more selective anti-inflammatory drugs, than COX inhibitors, to attenuate prostaglandin signaling, a fragment-based screen of hematopoietic prostaglandin D synthase was performed. The 76 crystallographic hits...
7.
Glibert P, Allen J, Artioli Y, Beusen A, Bouwman L, Harle J, et al.
Glob Chang Biol
. 2014 Jun;
20(12):3845-58.
PMID: 24942916
Harmful algal blooms (HABs), those proliferations of algae that can cause fish kills, contaminate seafood with toxins, form unsightly scums, or detrimentally alter ecosystem function have been increasing in frequency,...
8.
Chust G, Allen J, Bopp L, Schrum C, Holt J, Tsiaras K, et al.
Glob Chang Biol
. 2014 Mar;
20(7):2124-39.
PMID: 24604761
Ocean warming can modify the ecophysiology and distribution of marine organisms, and relationships between species, with nonlinear interactions between ecosystem components potentially resulting in trophic amplification. Trophic amplification (or attenuation)...
9.
Blanchard J, Jennings S, Holmes R, Harle J, Merino G, Allen J, et al.
Philos Trans R Soc Lond B Biol Sci
. 2012 Sep;
367(1605):2979-89.
PMID: 23007086
Existing methods to predict the effects of climate change on the biomass and production of marine communities are predicated on modelling the interactions and dynamics of individual species, a very...
10.
Pelham T, Holt L, Holt J
Am J Forensic Med Pathol
. 2010 Jan;
31(2):200-3.
PMID: 20110802
Kinesiology is the study of human movement, and comprises several disciplines, each devoted to a specific aspect of human activity, each with its own set of principles and methods to...