Daniel J Price
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Explore the profile of Daniel J Price including associated specialties, affiliations and a list of published articles.
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45
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1112
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Recent Articles
1.
Gonzalez-Bolivar M, De Marco O, Lau M, Hirai R, Price D
Mon Not R Astron Soc
. 2022 Oct;
517(3):3181-3199.
PMID: 36311180
At least one in five of all planetary nebulae are the product of a common envelope (CE) interaction, where the companion in-spirals into the envelope of an asymptotic giant branch...
2.
Chen E, Bondi R, Zhang C, Price D, Ho M, Armacost K, et al.
J Med Chem
. 2022 May;
65(9):6926-6939.
PMID: 35500041
Many critical decisions faced in early discovery require a thorough understanding of the dynamic behavior of pharmacological pathways following target engagement. From fundamental decisions on the optimal target to pursue...
3.
Schulte C, Deaton D, Diaz E, Do Y, Gampe R, Guss J, et al.
Bioorg Med Chem Lett
. 2021 May;
47:128113.
PMID: 33991628
Through an internal virtual screen at GlaxoSmithKline a distinct class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors were discovered. Careful evaluation of crystal structures and SAR led to a novel, potent, and orally...
4.
Koehl N, Henze L, Bennett-Lenane H, Faisal W, Price D, Holm R, et al.
Mol Pharm
. 2021 Apr;
18(6):2174-2188.
PMID: 33890794
The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic...
5.
Cadilla R, Deaton D, Do Y, Elkins P, Ennulat D, Guss J, et al.
Bioorg Med Chem
. 2020 Oct;
28(23):115791.
PMID: 33059303
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals....
6.
Struble T, Alvarez J, Brown S, Chytil M, Cisar J, DesJarlais R, et al.
J Med Chem
. 2020 Apr;
63(16):8667-8682.
PMID: 32243158
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing synthetic...
7.
Ditzinger F, Price D, Nair A, Becker-Baldus J, Glaubitz C, Dressman J, et al.
Pharmaceutics
. 2019 Nov;
11(11).
PMID: 31689980
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME),...
8.
Price D, Nair A, Becker-Baldus J, Glaubitz C, Kuentz M, Dressman J, et al.
Eur J Pharm Sci
. 2019 Oct;
141:105113.
PMID: 31655207
Mesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs). Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated API therefore, a...
9.
Price D, Nair A, Kuentz M, Dressman J, Saal C
Eur J Pharm Sci
. 2019 Mar;
132:142-156.
PMID: 30877067
Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation inhibitor (PI)...
10.
Deaton D, Do Y, Holt J, Jeune M, Kramer H, Larkin A, et al.
Bioorg Med Chem
. 2019 Mar;
27(8):1456-1478.
PMID: 30858025
With the goal of discovering more selective anti-inflammatory drugs, than COX inhibitors, to attenuate prostaglandin signaling, a fragment-based screen of hematopoietic prostaglandin D synthase was performed. The 76 crystallographic hits...