Jason E Imbriglio
Overview
Explore the profile of Jason E Imbriglio including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
259
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0
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Recent Articles
1.
Petrilli W, Adam G, Erdmann R, Abeywickrema P, Agnani V, Ai X, et al.
Cell Chem Biol
. 2021 Feb;
28(2):243.
PMID: 33607006
No abstract available.
2.
Daurio N, Zhou H, Chen Y, Sheth P, Imbriglio J, McLaren D, et al.
ACS Chem Biol
. 2020 Sep;
15(10):2623-2635.
PMID: 32930572
The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to...
3.
Petrilli W, Adam G, Erdmann R, Abeywickrema P, Agnani V, Ai X, et al.
Cell Chem Biol
. 2019 Oct;
27(1):32-40.e3.
PMID: 31653597
Proprotein convertase substilisin-like/kexin type 9 (PCSK9) is a serine protease involved in a protein-protein interaction with the low-density lipoprotein (LDL) receptor that has both human genetic and clinical validation. Blocking...
4.
McLaren D, Han S, Murphy B, Wilsie L, Stout S, Zhou H, et al.
Cell Metab
. 2018 May;
27(6):1236-1248.e6.
PMID: 29706567
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To...
5.
Chitraju C, Mejhert N, Haas J, Diaz-Ramirez L, Grueter C, Imbriglio J, et al.
Cell Metab
. 2017 Aug;
26(2):407-418.e3.
PMID: 28768178
Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and transported to other...
6.
Sanders J, Beshore D, Culberson J, Fells J, Imbriglio J, Gunaydin H, et al.
J Med Chem
. 2017 Apr;
60(16):6771-6780.
PMID: 28418656
High-throughput screening (HTS) has enabled millions of compounds to be assessed for biological activity, but challenges remain in the prioritization of hit series. While biological, absorption, distribution, metabolism, excretion, and...
7.
Imbriglio J, Shen D, Liang R, Marby K, You M, Youm H, et al.
J Med Chem
. 2015 Nov;
58(23):9345-53.
PMID: 26561979
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article...
8.
Song X, Zhang J, Chen X, Palyha O, Chung C, Sonatore L, et al.
J Biomol Screen
. 2015 Sep;
21(2):117-26.
PMID: 26403520
Mass spectrometry offers significant advantages over other detection technologies in the areas of hit finding, hit validation, and medicinal chemistry compound optimization. The foremost obvious advantage is the ability to...
9.
Eberhart A, Imbriglio J, Procter D
Org Lett
. 2011 Oct;
13(21):5882-5.
PMID: 21999481
Aryl and heteroaryl sulfoxides undergo ortho allylation upon treatment with Tf(2)O and allylsilanes. The method complements the use of sulfoxides to direct ortho-metalation and reaction with electrophiles as it allows...
10.
Imbriglio J, DiRocco D, Bodner R, Raghavan S, Chen W, Marley D, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(9):2721-4.
PMID: 21185185
Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties.