Shirly Pinto
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Explore the profile of Shirly Pinto including associated specialties, affiliations and a list of published articles.
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44
Citations
2431
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Recent Articles
1.
Richards P, Thornberry N, Pinto S
Mol Metab
. 2021 Feb;
46:101175.
PMID: 33548501
Background: The gut-brain axis, which mediates bidirectional communication between the gastrointestinal system and central nervous system (CNS), plays a fundamental role in multiple areas of physiology including regulating appetite, metabolism,...
2.
Zhang J, Wang T, Saigal A, Johnson J, Morrisson J, Tabrizifard S, et al.
Sci Rep
. 2021 Jan;
11(1):2118.
PMID: 33483531
Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types...
3.
Zhang J, Muise E, Han S, Kutchukian P, Costet P, Zhu Y, et al.
Cell Rep Med
. 2020 Nov;
1(4):100056.
PMID: 33205063
Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues...
4.
Zhang J, Vardy E, Muise E, Wang T, Visconti R, Vadlamudi A, et al.
J Pharmacol Exp Ther
. 2020 Aug;
375(2):357-366.
PMID: 32848074
Fibrosis or accumulation of extracellular matrix is an evolutionarily conserved mechanism adopted by an organism as a response to chronic injury. Excessive fibrosis, however, leads to disruption of organ homeostasis...
5.
Zhou X, Muise E, Haimbach R, Sebhat I, Zhu Y, Liu F, et al.
J Pharmacol Exp Ther
. 2019 Jul;
371(1):45-55.
PMID: 31300612
Metabolic dysregulation and mitochondrial dysfunction are important features of acute and chronic tissue injury across species, and human genetics and preclinical data suggest that the master metabolic regulator 5'-adenosine monophosphate-activated...
6.
Yu Y, Wu Z, Shi Z, He S, Lai Z, Cernak T, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1380-1385.
PMID: 30952592
The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1) inhibitors. Through a highly collaborative and iterative library design, synthesis and testing, a...
7.
He S, Lai Z, Hong Q, Shang J, Reibarkh M, Kuethe J, et al.
Bioorg Med Chem Lett
. 2019 Mar;
29(10):1182-1186.
PMID: 30926247
Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition...
8.
McLaren D, Han S, Murphy B, Wilsie L, Stout S, Zhou H, et al.
Cell Metab
. 2018 May;
27(6):1236-1248.e6.
PMID: 29706567
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To...
9.
Farrar C, Gale E, Kennan R, Ramsay I, Masia R, Arora G, et al.
Radiology
. 2017 Nov;
287(2):581-589.
PMID: 29156148
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in...
10.
Zhou X, Zhang J, Haimbach R, Zhu W, Mayer-Ezell R, Garcia-Calvo M, et al.
Pharmacol Res Perspect
. 2017 Oct;
5(5).
PMID: 28971604
Multiple integrins have been implicated in modulating renal function. Modulation of integrin function can lead to pathophysiological processes associated with diabetic nephropathy such as alterations in the glomerular filtration barrier...