Larissa Wilsie
Overview
Explore the profile of Larissa Wilsie including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
116
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0
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Recent Articles
1.
McLaren D, Han S, Murphy B, Wilsie L, Stout S, Zhou H, et al.
Cell Metab
. 2018 May;
27(6):1236-1248.e6.
PMID: 29706567
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To...
2.
Imbriglio J, Shen D, Liang R, Marby K, You M, Youm H, et al.
J Med Chem
. 2015 Nov;
58(23):9345-53.
PMID: 26561979
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article...
3.
Song X, Zhang J, Chen X, Palyha O, Chung C, Sonatore L, et al.
J Biomol Screen
. 2015 Sep;
21(2):117-26.
PMID: 26403520
Mass spectrometry offers significant advantages over other detection technologies in the areas of hit finding, hit validation, and medicinal chemistry compound optimization. The foremost obvious advantage is the ability to...
4.
Previs S, McLaren D, Wang S, Stout S, Zhou H, Herath K, et al.
Biochim Biophys Acta
. 2013 May;
1842(3):402-13.
PMID: 23707557
Our ability to understand the pathogenesis of problems surrounding lipid accretion requires attention towards quantifying lipid kinetics. In addition, studies of metabolic flux should also help unravel mechanisms that lead...
5.
Melone M, Wilsie L, Palyha O, Strack A, Rashid S
J Am Coll Cardiol
. 2012 May;
59(19):1697-705.
PMID: 22554600
Objectives: In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes. Background: Serum levels of...
6.
Schmidt D, Smenton A, Raghavan S, Shen H, Ding F, Carballo-Jane E, et al.
Bioorg Med Chem Lett
. 2010 May;
20(11):3426-30.
PMID: 20444602
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose...
7.
Schmidt D, Smenton A, Raghavan S, Carballo-Jane E, Lubell S, Ciecko T, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(16):4768-72.
PMID: 19592242
Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A...