Steven L Colletti
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Explore the profile of Steven L Colletti including associated specialties, affiliations and a list of published articles.
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53
Citations
877
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Recent Articles
1.
Stone S, Newman D, Colletti S, Tan D
Nat Prod Rep
. 2021 Aug;
39(1):20-32.
PMID: 34342327
Covering: 1981 to 2019Natural products continue to play a major role in drug discovery, with half of new chemical entities based structurally on a natural product. Herein, we report a...
2.
Pio B, Chobanian H, Guo Y, Josien H, Hagmann W, Miller M, et al.
Bioorg Med Chem Lett
. 2019 May;
29(14):1842-1848.
PMID: 31109791
GPR40 (FFAR1 or FFA1) is a G protein-coupled receptor, primarily expressed in pancreatic islet β-cells and intestinal enteroendocrine cells. When activated by fatty acids, GPR40 elicits increased insulin secretion from...
3.
Salter R, Beshore D, Colletti S, Evans L, Gong Y, Helmy R, et al.
Xenobiotica
. 2018 Aug;
49(8):877-886.
PMID: 30118378
Metabolite identification is an integral part of both preclinical and clinical drug discovery and development. Synthesis of drug metabolites is often required to support definitive identification, preclinical safety studies and...
4.
Zhang R, Li G, Wismer M, Vachal P, Colletti S, Shi Z
ACS Med Chem Lett
. 2018 Jul;
9(7):773-777.
PMID: 30034617
Recent visible-light photoredox catalyzed C(sp)-C(sp) cross-coupling provides a novel transformation to potentially enable the synthesis of medicinal chemistry targets. Here, we report a profiling study of photocatalytic C(sp)-C(sp) cross-coupling, both...
5.
Chen H, Plummer C, Xiao D, Chobanian H, DeMong D, Miller M, et al.
ACS Med Chem Lett
. 2018 Jul;
9(7):685-690.
PMID: 30034601
A series of biaryl chromans exhibiting potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM) were discovered as potential therapeutics for the treatment...
6.
Yu Y, Zhang L, Buevich A, Li G, Tang H, Vachal P, et al.
J Am Chem Soc
. 2018 May;
140(22):6797-6800.
PMID: 29762027
Targeting tryptophan is a promising strategy to achieve high levels of selectivity for peptide or protein modification. A chemoselective peptide modification method via photocatalytic tryptophan β-position conjugation has been discovered....
7.
Loh Y, Nagao K, Hoover A, Hesk D, Rivera N, Colletti S, et al.
Science
. 2017 Nov;
358(6367):1182-1187.
PMID: 29123019
Deuterium- and tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, providing vital information about the biological fate of drugs and drug metabolites. Herein we demonstrate that a...
8.
Pachanski M, Kirkland M, Kosinski D, Mane J, Cheewatrakoolpong B, Xue J, et al.
PLoS One
. 2017 Oct;
12(10):e0186033.
PMID: 29053717
GPR40 agonists are effective antidiabetic agents believed to lower glucose through direct effects on the beta cell to increase glucose stimulated insulin secretion. However, not all GPR40 agonists are the...
9.
Lu J, Byrne N, Wang J, Bricogne G, Brown F, Chobanian H, et al.
Nat Struct Mol Biol
. 2017 Jun;
24(7):570-577.
PMID: 28581512
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential mechanism for the treatment of type 2...
10.
Gorski J, Pachanski M, Mane J, Plummer C, Souza S, Thomas-Fowlkes B, et al.
Am J Physiol Endocrinol Metab
. 2017 Mar;
313(1):E37-E47.
PMID: 28292762
G protein-coupled receptor 40 (GPR40) partial agonists lower glucose through the potentiation of glucose-stimulated insulin secretion, which is believed to provide significant glucose lowering without the weight gain or hypoglycemic...