Jana Zecha
Overview
Explore the profile of Jana Zecha including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
1501
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, et al.
Nat Methods
. 2020 Apr;
17(5):495-503.
PMID: 32284610
We have used a mass spectrometry-based proteomic approach to compile an atlas of the thermal stability of 48,000 proteins across 13 species ranging from archaea to humans and covering melting...
12.
Bian Y, Zheng R, Bayer F, Wong C, Chang Y, Meng C, et al.
Nat Commun
. 2020 Jan;
11(1):157.
PMID: 31919466
Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC-MS/MS) is the mainstay in proteome research because of its excellent sensitivity but often comes at the expense of robustness. Here we show...
13.
Samaras P, Schmidt T, Frejno M, Gessulat S, Reinecke M, Jarzab A, et al.
Nucleic Acids Res
. 2019 Oct;
48(D1):D1153-D1163.
PMID: 31665479
ProteomicsDB (https://www.ProteomicsDB.org) started as a protein-centric in-memory database for the exploration of large collections of quantitative mass spectrometry-based proteomics data. The data types and contents grew over time to include...
14.
Khakipoor S, Giannaki M, Theparambil S, Zecha J, Kuster B, Heermann S, et al.
Glia
. 2019 Jul;
67(12):2264-2278.
PMID: 31318482
The electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), is the major bicarbonate transporter expressed in astrocytes. It is highly sensitive for bicarbonate and the main regulator of intracellular, extracellular, and...
15.
Zecha J, Satpathy S, Kanashova T, Avanessian S, Kane M, Clauser K, et al.
Mol Cell Proteomics
. 2019 Apr;
18(7):1468-1478.
PMID: 30967486
Isobaric stable isotope labeling using, for example, tandem mass tags (TMTs) is increasingly being applied for large-scale proteomic studies. Experiments focusing on proteoform analysis in drug time course or perturbation...
16.
Wang D, Eraslan B, Wieland T, Hallstrom B, Hopf T, Zolg D, et al.
Mol Syst Biol
. 2019 Feb;
15(2):e8503.
PMID: 30777892
Genome-, transcriptome- and proteome-wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are expressed and in which quantities...
17.
Zecha J, Meng C, Zolg D, Samaras P, Wilhelm M, Kuster B
Mol Cell Proteomics
. 2018 Feb;
17(5):974-992.
PMID: 29414762
The coordination of protein synthesis and degradation regulating protein abundance is a fundamental process in cellular homeostasis. Today, mass spectrometry-based technologies allow determination of endogenous protein turnover on a proteome-wide...
18.
Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig P, et al.
Science
. 2017 Dec;
358(6367).
PMID: 29191878
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243...
19.
Ruprecht B, Zaal E, Zecha J, Wu W, Berkers C, Kuster B, et al.
Cancer Res
. 2017 Feb;
77(8):1842-1853.
PMID: 28209619
HER2/ERBB2-overexpressing breast cancers targeted effectively by the small-molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study, we employed explorative mass spectrometry to profile proteome, kinome, and...
20.
Ruprecht B, Zecha J, Zolg D, Kuster B
Methods Mol Biol
. 2017 Feb;
1550:83-98.
PMID: 28188525
Despite recent advances in mass spectrometric sequencing speed and improved sensitivity, the in-depth analysis of proteomes still widely relies on off-line peptide separation and fractionation to deal with the enormous...