Simone Lemeer
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Explore the profile of Simone Lemeer including associated specialties, affiliations and a list of published articles.
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61
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3391
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Recent Articles
1.
Vennin C, Cattaneo C, Bosch L, Vegna S, Ma X, Damstra H, et al.
Cancer Cell
. 2023 Jun;
41(6):1170-1185.e12.
PMID: 37311414
Although treatment with taxanes does not always lead to clinical benefit, all patients are at risk of their detrimental side effects such as peripheral neuropathy. Understanding the in vivo mode...
2.
Leijten N, Heck A, Lemeer S
Nat Methods
. 2022 Jun;
19(7):827-828.
PMID: 35726056
It has been suggested that in mammalian cells histidine residues in proteins may become as frequently phosphorylated as serine, threonine and tyrosine, and may play a key role in mammalian...
3.
Prust N, van Breugel P, Lemeer S
Mol Cell Proteomics
. 2022 Apr;
21(5):100232.
PMID: 35421590
Arginine phosphorylation was only recently discovered to play a significant and relevant role in the Gram-positive bacterium Bacillus subtilis. In addition, arginine phosphorylation was also detected in Staphylococcus aureus, suggesting...
4.
Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galvan P, et al.
Breast Cancer Res
. 2021 Mar;
23(1):42.
PMID: 33785053
Background: Around 15-20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the successful development of anti-HER2 drugs, intrinsic and acquired resistance represents a...
5.
Leijten N, Bakker P, Spaink H, den Hertog J, Lemeer S
Mol Cell Proteomics
. 2021 Feb;
20:100033.
PMID: 33594990
Thermal proteome profiling (TPP) allows for the unbiased detection of drug-target protein engagements in vivo. Traditionally, 1 cell type is used for TPP studies, with the risk of missing important...
6.
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al.
Mol Cell
. 2021 Feb;
81(6):1170-1186.e10.
PMID: 33571422
The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whether...
7.
Prust N, van der Laarse S, van den Toorn H, Van Sorge N, Lemeer S
Mol Cell Proteomics
. 2021 Jan;
20:100034.
PMID: 33444734
Staphylococcus aureus is a major cause of infections worldwide, and infection results in a variety of diseases. As of no surprise, protein phosphorylation is an important game player in signaling...
8.
Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, et al.
J Clin Invest
. 2020 Apr;
130(6):2827-2844.
PMID: 32338640
Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function, and cancer susceptibility. Diagnosis of IBMFS presents a major challenge...
9.
Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, et al.
Nat Methods
. 2020 Apr;
17(5):495-503.
PMID: 32284610
We have used a mass spectrometry-based proteomic approach to compile an atlas of the thermal stability of 48,000 proteins across 13 species ranging from archaea to humans and covering melting...
10.
Potel C, Lin M, Prust N, van den Toorn H, Heck A, Lemeer S
Anal Chem
. 2019 Apr;
91(9):5542-5547.
PMID: 30969750
Recent technological advances have made it possible to investigate the hitherto rather elusive protein histidine phosphorylation. However, confident site-specific localization of protein histidine phosphorylation remains challenging. Here, we address this...