Jana Zecha
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Explore the profile of Jana Zecha including associated specialties, affiliations and a list of published articles.
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21
Citations
1501
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Recent Articles
1.
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Chang Y, Gnann C, Steimbach R, Bayer F, Lechner S, Sakhteman A, et al.
Cell Rep
. 2024 May;
43(6):114272.
PMID: 38795348
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action...
2.
Choudhury F, Premkumar V, Zecha J, Boyd J, Gaynor A, Guo Z, et al.
J Proteome Res
. 2024 Feb;
23(8):3096-3107.
PMID: 38417049
Fluorescence-activated cell sorting (FACS) is a specialized technique to isolate specific cell subpopulations with a high level of recovery and accuracy. However, the cell sorting procedure can impact the viability...
3.
Zecha J, Bayer F, Wiechmann S, Woortman J, Berner N, Muller J, et al.
Science
. 2023 Mar;
380(6640):93-101.
PMID: 36926954
Although most cancer drugs modulate the activities of cellular pathways by changing posttranslational modifications (PTMs), little is known regarding the extent and the time- and dose-response characteristics of drug-regulated PTMs....
4.
Ryan F, Norton T, McCafferty C, Blake S, Stevens N, James J, et al.
Cell Rep Med
. 2023 Mar;
4(3):100971.
PMID: 36871558
Identifying the molecular mechanisms that promote optimal immune responses to coronavirus disease 2019 (COVID-19) vaccination is critical for future rational vaccine design. Here, we longitudinally profile innate and adaptive immune...
5.
Paulmann C, Spallek R, Karpiuk O, Heider M, Schaffer I, Zecha J, et al.
EMBO J
. 2022 Sep;
41(20):e110871.
PMID: 36059274
Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities...
6.
Zecha J, Gabriel W, Spallek R, Chang Y, Mergner J, Wilhelm M, et al.
Nat Commun
. 2022 Jan;
13(1):165.
PMID: 35013197
Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labeling and mass spectrometry to measure the turnover...
7.
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al.
Mol Cell
. 2021 Feb;
81(6):1170-1186.e10.
PMID: 33571422
The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whether...
8.
Flosbach M, Oberle S, Scherer S, Zecha J, von Hoesslin M, Wiede F, et al.
Cell Rep
. 2020 Jul;
32(4):107957.
PMID: 32726622
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies. Nonetheless,...
9.
Frejno M, Meng C, Ruprecht B, Oellerich T, Scheich S, Kleigrewe K, et al.
Nat Commun
. 2020 Jul;
11(1):3639.
PMID: 32686665
Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action. We extend this paradigm to...
10.
Zecha J, Lee C, Bayer F, Meng C, Grass V, Zerweck J, et al.
Mol Cell Proteomics
. 2020 Jun;
19(9):1503-1522.
PMID: 32591346
As the COVID-19 pandemic continues to spread, thousands of scientists around the globe have changed research direction to understand better how the virus works and to find out how it...