Jan L Breslow
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Explore the profile of Jan L Breslow including associated specialties, affiliations and a list of published articles.
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77
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3155
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Recent Articles
1.
Da Rosa J, Aleman J, Mohabir J, Liang Y, Breslow J, Holt P
OMICS
. 2022 Dec;
26(12):660-670.
PMID: 36454164
Obesity has reached epidemic proportions in the United States, but little is known about the mechanisms of weight gain and weight loss. Integration of omics data is becoming a popular...
2.
Aleman J, Henderson W, Walker J, Ronning A, Jones D, Walter P, et al.
J Clin Transl Sci
. 2021 Aug;
5(1):e143.
PMID: 34422323
Introduction: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver disease that accompanies obesity and the metabolic syndrome. Excess fructose consumption can initiate or exacerbate NAFLD in...
3.
Walker J, Garcet S, Aleman J, Mason C, Danko D, Butler D, et al.
Sci Rep
. 2021 Apr;
11(1):7524.
PMID: 33790371
No abstract available.
4.
Walker J, Garcet S, Aleman J, Mason C, Danko D, Butler D, et al.
Sci Rep
. 2020 Aug;
10(1):14079.
PMID: 32826922
Obesity is accompanied by dysfunction of many organs, but effects on the skin have received little attention. We studied differences in epithelial thickness by histology and gene expression by Affymetrix...
5.
Walker J, Eckardt P, Aleman J, Da Rosa J, Liang Y, Iizumi T, et al.
J Clin Transl Res
. 2019 Mar;
4(2):122-135.
PMID: 30873501
Background And Aim: The metabolic syndrome (MetS) is a pathological condition comprised of abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. It has become a major threat globally, resulting in rapidly...
6.
Aleman J, Bokulich N, Swann J, Walker J, de Rosa J, Battaglia T, et al.
J Transl Med
. 2018 Sep;
16(1):244.
PMID: 30176893
Background: Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic changes. We assessed...
7.
Holt P, Aleman J, Walker J, Jiang C, Liang Y, de Rosa J, et al.
Int J Nutr
. 2018 Apr;
1(4):31-49.
PMID: 29683134
Adipose tissue inflammation is associated with obesity comorbidities. Reducing such inflammation may ameliorate these comorbidities. n-3 fatty acids have been reported to have anti-inflammatory properties in obesity, which may modulate...
8.
Aleman J, Iyengar N, Walker J, Milne G, Da Rosa J, Liang Y, et al.
J Endocr Soc
. 2017 Dec;
1(6):625-637.
PMID: 29264516
Context: Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages. In humans,...
9.
Ponda M, Liang Y, Kim J, Hutt R, Dowd K, Gilleaudeau P, et al.
Am J Clin Nutr
. 2017 Feb;
105(5):1230-1238.
PMID: 28228421
Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol...
10.
Ponda M, Breslow J
Proc Natl Acad Sci U S A
. 2016 Oct;
113(45):E7059-E7068.
PMID: 27791187
Chemokines and their receptors play a critical role in immune function by directing cell-specific movement. C-C chemokine receptor 7 (CCR7) facilitates entry of T cells into lymph nodes. CCR7-dependent chemotaxis...