Jeffrey M Friedman
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Explore the profile of Jeffrey M Friedman including associated specialties, affiliations and a list of published articles.
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141
Citations
10570
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Recent Articles
1.
Tan B, Hedbacker K, Kelly L, Zhang Z, Moura-Assis A, Luo J, et al.
Cell Metab
. 2025 Mar;
37(3):723-741.e6.
PMID: 40043692
Similar to most humans with obesity, diet-induced obese (DIO) mice have high leptin levels and fail to respond to the exogenous hormone, suggesting that their obesity is caused by leptin...
2.
Friedman J
Cell Metab
. 2025 Mar;
37(3):570-577.
PMID: 40043689
Over the last 30 years, our understanding of the causes of obesity has been transformed, and new, highly effective medicines for reducing weight have been developed. This remarkable progress marks...
3.
Munoz-Rojas A, Wang A, Pomeranz L, Reizis E, Stout-Delgado H, Miranda I, et al.
J Clin Invest
. 2024 Oct;
135(1).
PMID: 39480494
No abstract available.
4.
Tan H, Yin L, Tan Y, Ivanov J, Plucinska K, Ilanges A, et al.
Nature
. 2024 Oct;
636(8041):198-205.
PMID: 39478220
Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity of specific neural populations controlling appetite and metabolism. Leptin regulates food intake...
5.
Unda S, Pomeranz L, Marongiu R, Yu X, Kelly L, Hassanzadeh G, et al.
Sci Adv
. 2024 Oct;
10(41):eadp9150.
PMID: 39383230
Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)-mediated delivery of a...
6.
The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity
Friedman J
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2415550121.
PMID: 39297680
The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her...
7.
Tan B, Browne C, Nobauer T, Vaziri A, Friedman J, Nestler E
Science
. 2024 Apr;
384(6693):eadk6742.
PMID: 38669575
Drugs of abuse are thought to promote addiction in part by "hijacking" brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium...
8.
Tschop M, Friedman J
Sci Transl Med
. 2023 Nov;
15(723):eadh4453.
PMID: 37992155
Remedies for the treatment of obesity date to Hippocrates, when patients with obesity were directed to "reduce food and avoid drinking to fullness" and begin "running during the night." Similar...
9.
Tan B, Browne C, Nobauer T, Vaziri A, Friedman J, Nestler E
bioRxiv
. 2023 Sep;
PMID: 37732251
Addiction prioritizes drug use over innate needs by "hijacking" brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and single-neuron calcium imaging, we find...
10.
Unda S, Pomeranz L, Marongiu R, Yu X, Kelly L, Hassanzadeh G, et al.
bioRxiv
. 2023 Jul;
PMID: 37503198
Here we report a novel suite of magnetogenetic tools, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. AAV-mediated delivery of...