Jan Kristoff
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Explore the profile of Jan Kristoff including associated specialties, affiliations and a list of published articles.
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19
Citations
621
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Recent Articles
1.
Wu G, Keller S, Walters R, Li Y, Kristoff J, Magliaro B, et al.
Int J Mol Sci
. 2025 Jan;
26(2.
PMID: 39859395
Despite the success of combination antiretroviral therapy (cART) to suppress HIV replication, HIV persists in a long-lived reservoir that can give rise to rebounding viremia upon cART cessation. The translationally...
2.
Balibar C, Klein D, Zamlynny B, Diamond T, Fang Z, Cheney C, et al.
Sci Transl Med
. 2023 Feb;
15(684):eabn2038.
PMID: 36812345
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1...
3.
Kristoff J, Rinaldo C, Mailliard R
Viruses
. 2020 Jan;
12(1).
PMID: 31905690
The development of effective yet nontoxic strategies to target the latent human immunodeficiency virus-1 (HIV-1) reservoir in antiretroviral therapy (ART)-suppressed individuals poses a critical barrier to a functional cure. The...
4.
Kristoff J, Palma M, Garcia-Bates T, Shen C, Sluis-Cremer N, Gupta P, et al.
EBioMedicine
. 2019 Apr;
43:295-306.
PMID: 30952614
Background: Despite the success of antiretroviral therapy (ART), latent HIV-1 continues to persist in a long-lived population of resting memory CD4 T cells within those who are infected. Finding a...
5.
Pandrea I, Xu C, Stock J, Frank D, Ma D, Policicchio B, et al.
PLoS Pathog
. 2016 Jan;
12(1):e1005384.
PMID: 26764484
Increased chronic immune activation and inflammation are hallmarks of HIV/SIV infection and are highly correlated with progression to AIDS and development of non-AIDS comorbidities, such as hypercoagulability and cardiovascular disease....
6.
Hao X, Lucero C, Turkbey B, Bernardo M, Morcock D, Deleage C, et al.
Nat Commun
. 2015 Aug;
6:8020.
PMID: 26282376
Mucosal damage to the gastrointestinal (GI) tract with resulting microbial translocation is hypothesized to significantly contribute to the heightened and persistent chronic inflammation and immune activation characteristic to HIV infection....
7.
Ma D, Xu C, Cillo A, Policicchio B, Kristoff J, Haret-Richter G, et al.
J Virol
. 2015 Apr;
89(11):6155-60.
PMID: 25833043
Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to <0 to...
8.
Kristoff J, Haret-Richter G, Ma D, Ribeiro R, Xu C, Cornell E, et al.
J Clin Invest
. 2014 May;
124(6):2802-6.
PMID: 24837437
Damage to the intestinal mucosa results in the translocation of microbes from the intestinal lumen into the circulation. Microbial translocation has been proposed to trigger immune activation, inflammation, and coagulopathy,...
9.
Mandell D, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, et al.
J Virol
. 2014 Apr;
88(12):6778-92.
PMID: 24696477
Unlabelled: While simian immunodeficiency viruses (SIVs) are generally nonpathogenic in their natural hosts, dramatic increases in pathogenicity may occur upon cross-species transmission to new hosts. Deciphering the drivers of these...
10.
Ma D, Jasinska A, Feyertag F, Wijewardana V, Kristoff J, He T, et al.
J Virol
. 2014 Mar;
88(10):5687-705.
PMID: 24623416
Unlabelled: African green monkeys (AGMs) are naturally infected with simian immunodeficiency virus (SIV) at high prevalence levels and do not progress to AIDS. Sexual transmission is the main transmission route...