Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques As a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2015 Apr 3

PMID 25833043

Citations 15

Authors

Dongzhu Ma

Cuiling Xu

Anthony R Cillo

Benjamin Policicchio

Jan Kristoff

George Haret-Richter

John W Mellors

Ivona Pandrea

Cristian Apetrei

Affiliations

Soon will be listed here.

Abstract

Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to <0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8(+) cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding. This model permits assessment of strategies aimed at depleting the reservoir without multidrug antiretroviral therapy.

Citing Articles

Rapid systemic spread and minimal immune responses following SIVsab intrarectal transmission in African green monkeys.

Raehtz K, Xu C, Deleage C, Ma D, Policicchio B, Brocca-Cofano E JCI Insight. 2024; 9(23).

PMID: 39641272 PMC: 11623940. DOI: 10.1172/jci.insight.183751.

The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection.

Tolomeo M, Cascio A Int J Mol Sci. 2024; 25(14).

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Making a Monkey out of Human Immunodeficiency Virus/Simian Immunodeficiency Virus Pathogenesis: Immune Cell Depletion Experiments as a Tool to Understand the Immune Correlates of Protection and Pathogenicity in HIV Infection.

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Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers.

Khan M, Kim E, Le Hingrat Q, Kleinman A, Ferrari A, Sammartino J bioRxiv. 2023; .

PMID: 36993692 PMC: 10055053. DOI: 10.1101/2023.03.15.532808.

Prolonged experimental CD4 T-cell depletion does not cause disease progression in SIV-infected African green monkeys.

Le Hingrat Q, Sette P, Xu C, Rahmberg A, Tarnus L, Annapureddy H Nat Commun. 2023; 14(1):979.

PMID: 36813761 PMC: 9946951. DOI: 10.1038/s41467-023-36379-2.

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