Jan Eickhoff
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Explore the profile of Jan Eickhoff including associated specialties, affiliations and a list of published articles.
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35
Citations
1289
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Recent Articles
1.
Andlovic B, Wolf A, Hiltmann M, Klebl B, Eickhoff J, Ottmann C
SLAS Discov
. 2024 Nov;
29(8):100191.
PMID: 39510350
The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which has attracted interest in targeting the Hippo...
2.
Andlovic B, Valenti D, Centorrino F, Picarazzi F, Hristeva S, Hiltmann M, et al.
Biochemistry
. 2024 Aug;
63(17):2196-2206.
PMID: 39172504
The identification of chemical starting points for the development of molecular glues is challenging. Here, we employed fragment screening and identified an allosteric stabilizer of the complex between 14-3-3 and...
3.
Yu D, Wagner S, Schutz M, Jeon Y, Seo M, Kim J, et al.
Pharmaceutics
. 2024 Feb;
16(2).
PMID: 38399219
The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type...
4.
Bjornstad F, Havik S, Aarhus T, Mahdi I, Unger A, Habenberger P, et al.
Eur J Med Chem
. 2023 Dec;
265():116053.
PMID: 38141285
The colony-stimulating factor 1 receptor (CSF1R) is an attractive target for inflammation disorders and cancers. Based on a series of pyrrolo[2,3-d]pyrimidine containing two carbo-aromatic rings, we have searched for new...
5.
Wild M, Karner D, Eickhoff J, Wagner S, Kicuntod J, Chang W, et al.
Pharmaceutics
. 2023 Dec;
15(12).
PMID: 38140021
Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations. There is an urgent need for enhanced anti-HCMV drugs that...
6.
Schutz M, Wangen C, Sommerer M, Kogler M, Eickhoff J, Degenhart C, et al.
Virus Res
. 2023 Aug;
335:199200.
PMID: 37591314
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular...
7.
Sagurna L, Heinrich S, Kaufmann L, Ruckert-Reed C, Busche T, Wolf A, et al.
Antibiotics (Basel)
. 2023 Jul;
12(7).
PMID: 37508212
Bacteria of the genus produce various specialized metabolites. Single biosynthetic gene clusters (BGCs) can give rise to different products that can vary in terms of their biological activities. For example,...
8.
Aarhus T, Bjornstad F, Wolowczyk C, Larsen K, Rognstad L, Leithaug T, et al.
J Med Chem
. 2023 May;
66(10):6959-6980.
PMID: 37191268
Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible...
9.
Tillmanns J, Hage S, Borst E, Wardin J, Eickhoff J, Klebl B, et al.
Cells
. 2023 May;
12(8).
PMID: 37190072
Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a...
10.
Aarhus T, Eickhoff J, Klebl B, Unger A, Boros J, Choidas A, et al.
Eur J Med Chem
. 2023 May;
255:115344.
PMID: 37141705
The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective,...