Jan Eickhoff
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Explore the profile of Jan Eickhoff including associated specialties, affiliations and a list of published articles.
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35
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1289
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Recent Articles
11.
Andlovic B, Heilmann G, Ninck S, Andrei S, Centorrino F, Higuchi Y, et al.
Cell Chem Biol
. 2023 May;
30(6):573-590.e6.
PMID: 37130519
The natural product family of the fusicoccanes (FCs) has been shown to display anti-cancer activity, especially when combined with established therapeutic agents. FCs stabilize 14-3-3 protein-protein interactions (PPIs). Here, we...
12.
Wild M, Kicuntod J, Seyler L, Wangen C, Bertzbach L, Conradie A, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33430060
Human cytomegalovirus (HCMV) is a human pathogenic herpesvirus associated with a variety of clinical symptoms. Current antiviral therapy is not always effective, so that improved drug classes and drug-targeting strategies...
13.
Hansen K, Andersen J, Bayer A, Pandey S, Lorentzen M, Jorgensen K, et al.
J Med Chem
. 2019 Oct;
62(22):10167-10181.
PMID: 31647655
In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C-H...
14.
Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi H, et al.
Angew Chem Int Ed Engl
. 2019 Aug;
58(46):16617-16628.
PMID: 31454140
The Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting...
15.
Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler H, et al.
Stem Cell Reports
. 2019 Feb;
12(3):502-517.
PMID: 30773488
Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules...
16.
Sonntag E, Hahn F, Bertzbach L, Seyler L, Wangen C, Muller R, et al.
Antiviral Res
. 2018 Nov;
161:63-69.
PMID: 30452929
Infections with the human cytomegalovirus (HCMV) cause serious medical problems including organ rejection and congenital infection. Treatment of HCMV infections with currently available medication targeting viral enzymes is often accompanied...
17.
Sollberger G, Choidas A, Burn G, Habenberger P, Di Lucrezia R, Kordes S, et al.
Sci Immunol
. 2018 Aug;
3(26).
PMID: 30143555
The death of a cell is an inevitable part of its biology. During homeostasis, most cells die through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory forms...
18.
Gothert J, Imsak R, Mollmann M, Kesper S, Gobel M, Duhrsen U, et al.
Oncotarget
. 2018 Jun;
9(41):26353-26369.
PMID: 29899864
Onset of progression even during therapy with novel drugs remains an issue in chronic lymphocytic leukemia (CLL). Thus, there is ongoing demand for novel agents. Approaches targeting cyclin-dependent kinases (CDK)...
19.
Stevers L, Sijbesma E, Botta M, Mackintosh C, Obsil T, Landrieu I, et al.
J Med Chem
. 2017 Oct;
61(9):3755-3778.
PMID: 28968506
Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of protein-protein interactions (PPIs) has now been widely recognized as an...
20.
Lucking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, et al.
ChemMedChem
. 2017 Sep;
12(21):1776-1793.
PMID: 28961375
Selective inhibition of exclusively transcription-regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY-958, lead optimization efforts strictly focusing on kinase selectivity, physicochemical and DMPK...