Manfred Marschall
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Explore the profile of Manfred Marschall including associated specialties, affiliations and a list of published articles.
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147
Citations
2900
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Recent Articles
1.
Obergfall D, Wild M, Sommerer M, Barillas Dahm M, Kicuntod J, Tillmanns J, et al.
Pharmaceutics
. 2024 Sep;
16(9).
PMID: 39339274
. Cyclin-dependent kinase 8 (CDK8) is a multifaceted regulator and represents a catalytic component of the transcriptional Mediator complex. CDK8 activity, on the one hand, increases transcriptional elongation by the...
2.
Tillmanns J, Kicuntod J, Ehring A, Elbasani E, Borst E, Obergfall D, et al.
Pathogens
. 2024 Aug;
13(8).
PMID: 39204245
Human cytomegalovirus (HCMV) represents a highly medically important pathogen which has constantly been the subject of both molecular and clinical investigations. HCMV infections, especially those in high-risk patients, still raise...
3.
Marschall M, Schutz M, Wild M, Socher E, Wangen C, Dhotre K, et al.
Cells
. 2024 Aug;
13(16.
PMID: 39195228
Herpesviral protein kinases, such as the therapy-relevant pUL97 of human cytomegalovirus (HCMV), are important for viral replication efficiency as well as pathogenesis, and represent key antiviral drug targets. HCMV pUL97...
4.
Egilmezer E, Hamilton S, Lauw G, Follett J, Sonntag E, Schutz M, et al.
Viruses
. 2024 Jun;
16(6).
PMID: 38932210
Human cytomegalovirus (CMV) infection is the leading non-genetic cause of congenital malformation in developed countries, causing significant fetal injury, and in some cases fetal death. The pathogenetic mechanisms through which...
5.
Gege C, Hahn F, Wangen C, Hage S, Herrmann A, Uhlig N, et al.
ChemMedChem
. 2024 Jun;
19(19):e202400292.
PMID: 38887198
New strategies for the rapid development of broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Host-directed antivirals that...
6.
Egilmezer E, Hamilton S, Foster C, Marschall M, Rawlinson W
Commun Biol
. 2024 Mar;
7(1):340.
PMID: 38504123
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury. This study investigated potential CMV pathogenetic mechanisms of fetal neural...
7.
Tillmanns J, Kicuntod J, Losing J, Marschall M
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38474070
The herpesviral nuclear egress represents an essential step of viral replication efficiency in host cells, as it defines the nucleocytoplasmic release of viral capsids. Due to the size limitation of...
8.
Yu D, Wagner S, Schutz M, Jeon Y, Seo M, Kim J, et al.
Pharmaceutics
. 2024 Feb;
16(2).
PMID: 38399219
The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type...
9.
Wild M, Karner D, Eickhoff J, Wagner S, Kicuntod J, Chang W, et al.
Pharmaceutics
. 2023 Dec;
15(12).
PMID: 38140021
Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations. There is an urgent need for enhanced anti-HCMV drugs that...
10.
Schutz M, Cordsmeier A, Wangen C, Horn A, Wyler E, Ensser A, et al.
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38139252
The infection of human cytomegalovirus (HCMV) is strongly determined by the host-cell interaction in a way that the efficiency of HCMV lytic replication is dependent on the regulatory interplay between...