James H McKerrow
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Explore the profile of James H McKerrow including associated specialties, affiliations and a list of published articles.
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205
Citations
6263
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Recent Articles
1.
Spaulding A, Sharma A, Giardini M, Hoffman B, Bernatchez J, McCall L, et al.
ACS Infect Dis
. 2025 Feb;
11(3):584-599.
PMID: 39936822
Neglected tropical diseases such as Chagas disease, human African trypanosomiasis, leishmaniasis, and schistosomiasis have a significant global health impact in predominantly developing countries, although these diseases are spreading due to...
2.
Balogun E, Joseph G, Olabode S, Dayaso N, Danazumi A, Bashford-Rogers R, et al.
Pathogens
. 2024 Oct;
13(10).
PMID: 39452722
Human schistosomiasis, caused by the trematode, is a neglected parasitic disease affecting over 250 million people worldwide. There is no vaccine, and the single available drug is threatened by drug...
3.
Saidu U, Ibrahim M, de Koning H, McKerrow J, Caffrey C, Balogun E
Parasitol Res
. 2023 Oct;
122(12):2751-2772.
PMID: 37851179
Schistosomiasis is a neglected tropical disease caused by a parasitic, trematode blood fluke of the genus Schistosoma. With 20 million people infected, mostly due to Schistosoma haematobium, Nigeria has the...
4.
Usman M, Natala A, Jatau I, Ogo N, Jeelani G, Goto Y, et al.
Front Cell Infect Microbiol
. 2023 Sep;
13:1219629.
PMID: 37719668
Introduction: Female sand flies are hematophagous, feeding on animals and in the process serve as vectors for , the parasites that cause leishmaniasis in humans. Leishmaniasis are a group of...
5.
Kavouris J, McCall L, Giardini M, De Muylder G, Thomas D, Garcia-Perez A, et al.
Front Trop Dis
. 2023 Feb;
3.
PMID: 36818551
Introduction: Leishmaniasis is a parasitic disease that affects more than 1 million people worldwide annually, predominantly in resource-limited settings. The challenge in compound development is to exhibit potent activity against...
6.
da Silva E, Rebello K, Choi Y, Gregorio V, Paschoal A, Mitreva M, et al.
Pathogens
. 2022 Nov;
11(11).
PMID: 36365024
RNA sequencing (RNA-Seq) and mass-spectrometry-based proteomics data are often integrated in proteogenomic studies to assist in the prediction of eukaryote genome features, such as genes, splicing, single-nucleotide (SNVs), and single-amino-acid...
7.
Santos L, Kronenberger T, Almeida R, Silva E, Rocha R, Oliveira J, et al.
J Chem Inf Model
. 2022 Aug;
62(24):6553-6573.
PMID: 35960688
The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (M) and papain-like protease (PL) are attractive drug targets among coronaviruses due...
8.
Meewan I, Kattoula J, Kattoula J, Skinner D, Fajtova P, Giardini M, et al.
Pharmaceuticals (Basel)
. 2022 Jun;
15(6).
PMID: 35745663
One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or...
9.
Pillaiyar T, Flury P, Kruger N, Su H, Schakel L, Barbosa da Silva E, et al.
J Med Chem
. 2022 Jun;
65(13):9376-9395.
PMID: 35709506
The main protease (M, 3CL) of SARS-CoV-2 is an attractive target in coronaviruses because of its crucial involvement in viral replication and transcription. Here, we report on the design, synthesis,...
10.
Bernatchez J, Kil Y, Barbosa da Silva E, Thomas D, McCall L, Wendt K, et al.
ACS Omega
. 2022 Mar;
7(9):7675-7682.
PMID: 35284725
Safe and effective treatments for Chagas disease, a potentially fatal parasitic infection associated with cardiac and gastrointestinal pathology and caused by the kinetoplastid parasite , have yet to be developed....