Jair L Siqueira-Neto
Overview
Explore the profile of Jair L Siqueira-Neto including associated specialties, affiliations and a list of published articles.
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58
Citations
1077
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Recent Articles
1.
Godinez-Macias K, Chen D, Wallis J, Siegel M, Adam A, Bopp S, et al.
NPJ Drug Discov
. 2025 Mar;
2(1):3.
PMID: 40066064
Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this...
2.
Spaulding A, Sharma A, Giardini M, Hoffman B, Bernatchez J, McCall L, et al.
ACS Infect Dis
. 2025 Feb;
11(3):584-599.
PMID: 39936822
Neglected tropical diseases such as Chagas disease, human African trypanosomiasis, leishmaniasis, and schistosomiasis have a significant global health impact in predominantly developing countries, although these diseases are spreading due to...
3.
Nunes J, Santos-Junior P, Gomes M, Ferreira L, Padilha E, Teixeira T, et al.
Eur J Med Chem
. 2024 Dec;
283():117109.
PMID: 39653622
Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand innovative drug development due to their impact on public health worldwide. Their cysteine proteases, Cruzain (CRZ) and the T....
4.
Godinez-Macias K, Chen D, Wallis J, Siegel M, Adam A, Bopp S, et al.
Res Sq
. 2024 Dec;
PMID: 39649165
The identification of novel drug targets for the purpose of designing small molecule inhibitors is key component to modern drug discovery. In malaria parasites, discoveries of antimalarial targets have primarily...
5.
Rubio-Hernandez M, Alcolea V, Barbosa da Silva E, Giardini M, M Fernandes T, Martinez-Saez N, et al.
J Med Chem
. 2024 Nov;
67(21):19038-19056.
PMID: 39485736
Chagas disease is caused by the eukaryote parasite . Current treatment exhibits limited efficacy and selenium-based compounds emerged as promising candidates for new therapies which is surpassing its bioisoster, sulfur....
6.
Siqueira-Neto J, Wicht K, Chibale K, Burrows J, Fidock D, Winzeler E
Nat Rev Drug Discov
. 2024 Sep;
23(11):880.
PMID: 39271962
No abstract available.
7.
Silva T, Thomas D, Siqueira-Neto J, Calvet C
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000409
Cardiac fibrosis is a severe outcome of Chagas disease (CD), caused by the protozoan . Clinical evidence revealed a correlation between fibrosis levels with impaired cardiac performance in CD patients....
8.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Nat Commun
. 2024 Jan;
15(1):937.
PMID: 38297033
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
9.
Siqueira-Neto J, Wicht K, Chibale K, Burrows J, Fidock D, Winzeler E
Nat Rev Drug Discov
. 2023 Aug;
22(10):807-826.
PMID: 37652975
Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and improving dosing convenience. Discovery efforts have yielded a variety...
10.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Res Sq
. 2023 Aug;
PMID: 37546892
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...